Pathological and therapeutic effects of extracellular vesicles in neurological and neurodegenerative diseases  

作　　者：Paula lzquierdo-Altarejos Victoria Moreno-Manzano Vicente Felipo 

机构地区：[1]Laboratory of Neurobiology,Centro Investigación Príncipe Felipe,Valencia,Spain [2]Neuronal and Tissue Regeneration Laboratory,Centro Investigación Príncipe Felipe,Valencia,Spain

出　　处：《Neural Regeneration Research》2024年第1期55-61,共7页中国神经再生研究（英文版）

基　　金：supported in part by the Ministerio de Ciencia e Innovacion Spain(PID2020-113388RB-I00 to VF and PID2021-124359OB-100 to VMM);Conselleria Educacion Generalitat Valenciana(CIPROM/2021/082 to VF);co-funded with European Regional Development Funds(ERDF)to VF and VMM。

摘　　要：Extracellular vesicles are released by all cell types and contain proteins,microRNAs,mRNAs,and other bioactive molecules.Extracellular vesicles play an important role in intercellular communication and in the modulation of the immune system and neuroinflammation.The cargo of extra cellular vesicles(e.g.,proteins and microRNAs)is altered in pathological situations.Extracellular vesicles contribute to the pathogenesis of many pathologies associated with sustained inflammation and neuroinflammation,including cance r,diabetes,hype rammonemia and hepatic encephalopathy,and other neurological and neurodegenerative diseases.Extracellular vesicles may cross the blood-brain barrier and transfer pathological signals from the periphery to the brain.This contributes to inducing neuroinflammation and cognitive and motor impairment in hyperammonemia and hepatic encephalopathy and in neurodegenerative diseases.The mechanisms involved are beginning to be unde rstood.For example,increased tumor necrosis factor a in extracellular vesicles from plasma of hype rammonemic rats induces neuroinflammation and motor impairment when injected into normal rats.Identifying the mechanisms by which extracellular vesicles contribute to the pathogenesis of these diseases will help to develop new treatments and diagnostic tools for their easy and early detection.In contrast,extra cellular vesicles from mesenchymal stem cells have therapeutic utility in many of the above pathologies,by reducing inflammation and neuroinflammation and improving cognitive and motor function.These extra cellular vesicles recapitulate the beneficial effects of mesenchymal stem cells and have advantages as therapeutic tools:they are less immunoge nic,may not diffe rentiate to malignant cells,cross the blood-brain barrier,and may reach more easily target organs.Extracellular vesicles from mesenchymal stem cells have beneficial effects in models of ischemic brain injury,Alzheimer's and Parkinson's diseases,hyperammonemia,and hepatic encephalopathy.Extracellular vesicles f

关 键 词：extracellular vesicles INFLAMMATION cognitive function mesenchymal stem cells neurodegenerative diseases NEUROINFLAMMATION THERAPY transforming growth factor-β 

分 类 号：R741.02[医药卫生—神经病学与精神病学]