Lactate metabolism in neurodegenerative diseases  

作　　者：Chaoguang Yang Rui-Yuan Pan Fangxia Guan Zengqiang Yuan 

机构地区：[1]The Brain Science Center,Beijing Institute of Basic Medical Sciences,Beijing,China [2]School of Life Sciences,Zhengzhou University,Zhengzhou,Henan Province,China

出　　处：《Neural Regeneration Research》2024年第1期69-74,共6页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.82230042 and 81930029(to ZY),U2004201(to FG and RYP);the China Postdoctoral Science Foundation,No.2020M683748(to RYP)。

摘　　要：Lactate,a byproduct of glycolysis,was thought to be a metabolic waste until the discovery of the Warburg effect.Lactate not only functions as a metabolic substrate to provide energy but can also function as a signaling molecule to modulate cellular functions under pathophysiological conditions.The Astrocyte-Neuron Lactate Shuttle has cla rified that lactate plays a pivotal role in the central nervous system.Moreover,protein lactylation highlights the novel role of lactate in regulating transcription,cellular functions,and disease development.This review summarizes the recent advances in lactate metabolism and its role in neurodegenerative diseases,thus providing optimal pers pectives for future research.

关 键 词：Alzheimer's disease Astrocyte-Neuron Lactate Shuttle brain central nervous system glucose metabolism GLYCOLYSIS NEUROINFLAMMATION Parkinson's disease protein lactylation signaling molecule 

分 类 号：R741.02[医药卫生—神经病学与精神病学]