Ruthenium-catalyzed enantioselective hydrogenation of quinoxalinones and quinazolinones  

作　　者：Chenghao Li Shuxin Zhang Shan Li Yu Feng Qing-Hua Fan 

机构地区：[1]Beijing National Laboratory for Molecular Sciences,CAS Key Laboratory of Molecular Recognition and Function,Institute of Chemistry,Chinese Academy of Sciences(CAS),and University of Chinese Academy of Sciences,Beijing 100190,P.R.China

出　　处：《Organic Chemistry Frontiers》2022年第2期400-406,共7页有机化学前沿（英文）

基　　金：the National Natural Science Foundation of China(No.21871270,21790332 and 21521002);CAS(QYZDJSSWSLH023);the Youth Innovation Promotion Association,Chinese Academy of Sciences(201708)for financial support.

摘　　要：An efficient Ru-catalyzed enantioselective hydrogenation of quinoxalinone and quinazolinone derivatives has been successfully developed,providing a straightforward and facile access to chiral dihydroquinoxalinones and dihydroquinazolinones with excellent results(89-98% yields,up to 98%ee).Importantly,the key enantiopure dihydroquinoxalinone intermediate towards the synthesis of a bioactive BRD4 inhibitor was conveniently synthesized by this catalytic hydrogenation methodology.

关 键 词：HYDROGENATION CATALYZED ENANTIOSELECTIVE 

分 类 号：O62[理学—有机化学]