Repetitive transcranial magnetic stimulation combined with olanzapine and amisulpride for treatment-refractory schizophrenia  

作　　者：Jin-Ling Liu Zhi-Mei Tan Shu-Jie Jiao 

机构地区：[1]Department of Neurology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan Province,China [2]Department of Rehabilitation Medicine,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan Province,China

出　　处：《World Journal of Psychiatry》2023年第7期453-460,共8页世界精神病学杂志

摘　　要：BACKGROUND Treatment-refractory schizophrenia(TRS),accounting for approximately 30%of all schizophrenia cases,has poor treatment response and prognosis despite treatment with antipsychotic drugs.AIM To analyze the therapeutic effectiveness of repetitive transcranial magnetic stimulation(rTMS)combined with olanzapine(OLZ)and amisulpride(AMI)for TRS and its influence on the patient’s cognitive function.METHODS This study enrolled 114 TRS patients who received treatment at the First Affiliated Hospital of Zhengzhou University between July 2019 and July 2022.In addition to the basic OLZ+AMI therapy,54 cases of the control group(Con group)received modified electroconvulsive therapy,while 60 cases of the research group(Res group)received rTMS.Data on therapeutic effectiveness,safety(incidence of drowsiness,headache,nausea,vomiting,or memory impairment),Positive and Negative Symptom Scale,Montreal Cognitive Assessment Scale,and Schizophrenia Quality of Life Scale were collected from both cohorts for comparative analyses.RESULTS The Res group elicited a higher overall response rate and better safety profile when compared with the Con group.Additionally,a significant reduction was observed in the post-treatment Positive and Negative Symptom Scale and Schizophrenia Quality of Life Scale scores of the Res group,presenting lower scores than those of the Con group.Furthermore,a significant increase in the Montreal Cognitive Assessment Scale score was reported in the Res group,with higher scores than those of the Con group.CONCLUSION The treatment of TRS with rTMS and OLZ+AMI is effective and safe.Moreover,it can alleviate the patients’mental symptoms,improve their cognitive function and quality of life,and has a high clinical application value.

关 键 词：Repetitive transcranial magnetic stimulation OLANZAPINE AMISULPRIDE Treatment-refractory schizophrenia Therapeutic effectiveness Cognitive function 

分 类 号：R749.3[医药卫生—神经病学与精神病学]