OLANZAPINE

作品数:47被引量:43H指数:3
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相关领域:医药卫生更多>>
相关作者:刘进国邹晓庭黄爱霞宋云珍李彦杰更多>>
相关机构:浙江大学台湾大学西南大学苏州大学更多>>
相关期刊:《Acta Pharmacologica Sinica》《Oncology and Translational Medicine》《Surgical Science》《Chinese Medical Journal》更多>>
相关基金:国家自然科学基金国家高技术研究发展计划湖北省自然科学基金更多>>
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Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia
《World Journal of Psychiatry》2025年第1期37-53,共17页Yan-Ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu Jiao Wen-Hua Wan Hong-Wei Zhang Xiao Guo Hua Guo Shou-Feng Jia Xiao-Xin Li Shi-Xian Cao Li-Bin Fu Meng-Meng Liu Tian Zhou Lv-Feng Zhang Qing-Quan Jia 
Supported by Henan Provincial Science and Technology Research Project,No.242102310203.
BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for r...
关键词:SCHIZOPHRENIA Violent aggression OLANZAPINE Metabolomics Network pharmacology 
Activation of the PERK-CHOP signaling pathway during endoplasmic reticulum stress contributes to olanzapine-induced dyslipidemia
《Acta Pharmacologica Sinica》2024年第3期502-516,共15页Lu Liu Lei Tang Jia-ming Luo Si-yu Chen Chun-yan Yi Xue-mei Liu Chang-hua Hu 
supported by the Chongqing Basic Research and Frontier Exploration Project(cstc2022ycjh-bgzxm0119).
Olanzapine(OLZ)is a widely prescribed antipsychotic drug with a relatively ideal effect in the treatment of schizophrenia(SCZ).However,its severe metabolic side effects often deteriorate clinical therapeutic complianc...
关键词:antipsychotic drug OLANZAPINE lipid metabolism disorder endoplasmic reticulum stress SREBPs PERK-CHOP signaling pathway 
HFD-exacerbated Metabolic Side Effects of Olanzapine Are Suppressed by ER Stress Inhibitor被引量:1
《Current Medical Science》2023年第6期1116-1132,共17页Yu-feng ZUO Bao-hua ZHANG Ming-rui GUO Ben-ben LI Bao-cui WANG Deng DUAN Yu-xin WANG Jing XI Meng HE Tao-lei SUN 
the Natural Science Foundation of Hubei Province(No.2021CFB301 and No.2021CFB299);the State Key Laboratory of Advanced Technology for Materials Synthesis and Processing(WUT)(No.2022-KF-27).
Objective Numerous schizophrenic patients are suffering from obesity primarily attributed to antipsychotic medication and poor dietary habits.This study investigated the progressive deterioration of olanzapine-induced...
关键词:OLANZAPINE high-fat diet OBESITY lipid metabolism endoplasmic reticulum stress PROOPIOMELANOCORTIN NOD-like receptor pyrin domain-containing protein 3 
Is Dosage Adjustment for Olanzapine Really Necessary?
《Open Journal of Psychiatry》2023年第3期187-206,共20页Kelvin N. Christie 
Schizophrenia is a prevalent and disabling disorder, commonly treated with medications such as clozapine and olanzapine. However, long-term side effects and limitations of these drugs, coupled with treatment resistanc...
关键词:SCHIZOPHRENIA KIDNEY LIVER Olanzapine (OLZ) 
Repetitive transcranial magnetic stimulation combined with olanzapine and amisulpride for treatment-refractory schizophrenia被引量:2
《World Journal of Psychiatry》2023年第7期453-460,共8页Jin-Ling Liu Zhi-Mei Tan Shu-Jie Jiao 
BACKGROUND Treatment-refractory schizophrenia(TRS),accounting for approximately 30%of all schizophrenia cases,has poor treatment response and prognosis despite treatment with antipsychotic drugs.AIM To analyze the the...
关键词:Repetitive transcranial magnetic stimulation OLANZAPINE AMISULPRIDE Treatment-refractory schizophrenia Therapeutic effectiveness Cognitive function 
Clinical Study on Jieyu Anshen Decoction Combined with Olanzapine in the Treatment of Insomnia Patients' Bad Mood and Sleep Disorder
《外文科技期刊数据库(文摘版)医药卫生》2022年第10期026-029,共4页HUCuiping WANGChangyin 
Objective: To observe the clinical study of Jieyu Anshen Decoction combined with olanzapine in the treatment of insomnia patients with bad mood and sleep disorders. Methods: In this study, 112 insomnia patients from O...
关键词:Jieyu Anshen decoction OLANZAPINE INSOMNIA bad mood sleep quality clinical efficacy 
Clinical Analysis of the Effect of Tandospirone Combined with Olanzapine on Cognitive Function of Schizophrenia Patients
《外文科技期刊数据库(文摘版)医药卫生》2022年第7期075-078,共4页YANFengmei 
Objective: to study and explore the effect of tandospirone+olanzapine on schizophrenia. Methods: in this study, 80 hospitalized patients with PANSS scores higher than 60 at admission from October 2018 to October 2019 ...
关键词:TANDOSPIRONE OLANZAPINE SCHIZOPHRENIA cognitive function 
Efficacy and safety of the combination of agomelatine and low-dose olanzapine in 184 cases of postprandial distress syndrome with depression,anxiety and sleep disorders
《China Medical Abstracts(Internal Medicine)》2022年第1期46-47,共2页WANG Xin 
Objective To observe the efficacy and safety of the combination of agomelatine and low-dose olanzapine(AO)in the treatment of postprandial distress syndrome(PDS)with depression,anxiety and sleep disorders.Methods From...
关键词:DISTRESS sleep DISORDERS 
Olanzapine-induced acute necrotising pancreatitis leading to recurrent multiple organ dysfunction syndrome
《General Psychiatry》2022年第1期53-56,共4页Stelios Naxakis Meghan Wafer Ruth Collins 
SUMMARY A married mother in her 50s acutely developed vomiting,diarrhoea and severe epigastric pain 2 weeks following discharge from an acute psychiatric inpatient unit.She presented to the emergency department compla...
关键词:PANCREATITIS ACUTE Blood 
The Efficacy of Escitalopram Combined with Olanzapine in Depression:A Systematic Review and Meta-analysis被引量:1
《World Journal of Integrated Traditional and Western Medicine》2021年第5期24-35,共12页SUN Xuan WANG Zhe MIAO Tian-de WANG Dong-jun GUAN Yuan-yuan TIAN Zhi-kui TIAN Chun-ying ZHU Qing-qing ZHOU Zong-hui BU Huai-en WANG Hong-wu 
Background:Depression will become the second most common disease after coronary heart disease(CHD).Escitalopram and olanzapine are commonly used to treat depression.Some studies indicated that escitalopram combined wi...
关键词:ESCITALOPRAM OLANZAPINE DEPRESSION META-ANALYSIS Randomized controlled trials 
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