supported by the National Natural Science Foundation of China(81401127);the Clinical Research Project of Shanghai Municipal Health Commission(20204Y0173);the Open Project Program of State Key Laboratory of Virtual Reality Technology and Systems,Beihang University(VRLAB2022 B02);the Shanghai Key Laboratory of Psychotic Disorders Open Grant(21-K03);the Scientific Research Project of Traditional Chinese Medicine of Guangdong(20192070);the Guangzhou Municipal Key Discipline in Medicine(2021–2023);the Science and Technology Plan Project of Guangdong Province(2019B030316001).
Background:Although clozapine is an effective option for treatment-resistant schizophrenia(TRS),there are still 1/3 to 1/2 of TRS patients who do not respond to clozapine.The main purpose of this randomized,double-bli...
BACKGROUND Treatment-refractory schizophrenia(TRS),accounting for approximately 30%of all schizophrenia cases,has poor treatment response and prognosis despite treatment with antipsychotic drugs.AIM To analyze the the...
OBJECTIVE To explain the high inter-individual variability and the frequency of exceeding the therapeutic reference range and the laboratory alert level of amisulpride,a popula⁃tion pharmacokinetic model in Chinese pa...