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作 者:Balázs Sarkadi
机构地区:[1]Institute of Enzymology,Research Centre for Natural Sciences,Budapest 1117,Hungary
出 处:《Cancer Drug Resistance》2023年第2期239-241,共3页癌症耐药(英文)
摘 要:A major problem in current cancer drug treatment is that a subset of cancer cells in many cases survives even highly efficient chemotherapy,and after a while,these remaining cells cause a recurrence of the disease.Moreover,the re-emerging cancer cells often show a multidrug-resistant phenotype,higher proliferation rate,higher invasiveness,and increased metastatic potential,as compared to original cancer.Cancer relapse and multidrug resistance are widely observed also in the most up-to-date,specifically targeted drug-or immunotherapies,causing an unsurmountable clinical inefficiency in cancer eradication.
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