Effects of curcumin on uterine leiomyoma in a rat model by inhibiting β-catenin/Wnt signaling pathway  

作　　者：Wen-Xian Li Jia-Li Bai Li Fu Ya-Jing Zhu Ge Fan Bing Yang Cheng-Liang Yin 

机构地区：[1]Research and Development Department,Beijing Life Biosciences Co.,Ltd.,Beijing 100176,China [2]Department of Clinical Pharmacy,Changzhi Maternal and Child Health Care Hospital,Changzhi 046000,China [3]College of Materials and Environmental Engineering,Hangzhou Dianzi University,Hangzhou 310018,China [4]Department of Obstetrics and Gynecology,Bejing Luhe Hospital Affiliated to Capital Medical University,Beijing 101100,China [5]Lightspeed and Quantum Studios,Tencent Inc.,Shenzhen 518000,China [6]Department of Cell Biology,College of Basic Medical Sciences,Tianjin Medical University,Tianjin 300070,China [7]National Engineering Laboratory for Medical Big Data Application Technology,Chinese People’s Liberation Army General Hospital,Beijing 100853,China

出　　处：《Precision Medicine Research》2023年第2期1-7,共7页精准医学研究

摘　　要：Background:Women with uterine leiomyomas may suffer severe symptoms.To avoid risks of side effects,it is necessary to develop an optimal agent to shrink leiomyomas with fewer side effects and a lower recurrence rate.Curcumin may have a lower side effect in uterine leiomyoma treatment.Methods:We established the estrogen-and-progesterone-induced murine model of uterine leiomyoma.Next,we determined the expression of related genes of the β-catenin/Wnt signaling pathway by western blot,reverse transcription-polymerase chain reaction,and immunohistochemistry.We also noticed the morphological changes in uterine tissues by hematoxylin-eosin staining.Results:Curcumin plays an important role in Wnt/β-catenin signaling pathway-related expression including β-catenin,adenomatous polyposis coli,glycogen synthase kinase-3β,Wnt-11,and serum hormone concentrations.Conclusions:Curcumin could the down-regulation of serum hormone concentrations and inhibition of the β-catenin/Wnt signaling pathway in the treatment of uterine leiomyoma.

关 键 词：LEIOMYOMA CURCUMIN Wnt signaling pathway ESTROGENS PROGESTERONE 

分 类 号：R73[医药卫生—肿瘤]