A self-monitoring microneedle patch for light-controlled synergistic treatment of melanoma  

作　　者：Chenyuan Wang Yongnian Zeng Kai-Feng Chen Jiawei Lin Qianqian Yuan Xue Jiang Gaosong Wu Fubing Wang Yong-Guang Jia Wei Li 

机构地区：[1]Department of Thyroid and Breast Surgery,Zhongnan Hospital of Wuhan University,School of Pharmaceutical Sciences,Wuhan University,Wuhan,430071,China [2]School of Materials Science and Engineering,South China University of Technology,Guangzhou,Guangdong,510641,China [3]TaiKang Center for Life and Medical Sciences,Wuhan University,Wuhan,China [4]Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center,Zhongnan Hospital of Wuhan University,Wuhan,China [5]Wuhan Research Center for Infectious Diseases and Cancer,Chinese Academy of Medical Sciences,Wuhan,China

出　　处：《Bioactive Materials》2023年第9期58-71,共14页生物活性材料（英文）

基　　金：support from the following fundings:National Natural Science Foundation of China(NSFC,No.52103182,21704026,22075087);Natural Science Foundation of Hubei Province(No.2021CFB103);the Fundamental Research Funds for the Central Universities(No.2042021kf0073).

摘　　要：Melanoma is the most aggressive and malignant form of skin cancer.Current melanoma treatment methods generally suffer from frequent drug administration as well as difficulty in direct monitoring of drug release.Here,a self-monitoring microneedle(MN)-based drug delivery system,which integrates a dissolving MN patch with aggregation-induced emission(AIE)-active PATC microparticles,is designed to achieve light-controlled pulsatile chemo-photothermal synergistic therapy of melanoma.The PATC polymeric particles,termed D/I@PATC,encapsulate both of chemotherapeutic drug doxorubicin(DOX)and the photothermal agent indocyanine green(ICG).Upon light illumination,PATC gradually dissociates into smaller particles,causing the release of encapsulated DOX and subsequent fluorescence intensity change of PATC particles,thereby not only enabling direct observation of the drug release process under light stimuli,but also facilitating verification of drug release by fluorescence recovery after light trigger.Moreover,encapsulation of ICG in PATC particles displays significant improvement of its photothermal stability both in vitro and in vivo.In a tumor-bearing mouse,the application of one D/I@PATC MN patch combining with two cycles of light irradiation showed excellent controllable chemo-photothermal efficacy and exhibited~97%melanoma inhibition rate without inducing any evident systemic toxicity,suggesting a great potential for skin cancer treatment in clinics.

关 键 词：MICRONEEDLE Controlled release MELANOMA AIE Photothermal therapy Chemotherapy 

分 类 号：R739.5[医药卫生—肿瘤]