The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies  

作　　者：Hengwei Zhang Jane LLiesveld Laura MCalvi Brea CLipe Lianping Xing Michael WBecker Edward MSchwarz Shu-Chi A.Yeh 

机构地区：[1]Center for Musculoskeletal Research,University of Rochester Medical Center,601 Elmwood Ave,Box 665,Rochester,NY14642,USA [2]Department of Pathology and Laboratory Medicine,University of Rochester Medical Center,Rochester,NY,USA [3]Wilmot Cancer Center,University of Rochester Medical Center,Rochester,NY,USA [4]Department of Medicine,Division of Hematology/Oncology and Bone Marrow Transplantation Program,University of Rochester Medical Center,Rochester,NY,USA [5]Department of Medicine,Division of Endocrinology/Metabolism,University of Rochester Medical Center,Rochester,NY,USA [6]Department of Orthopaedics,University of Rochester Medical Center,Rochester,NY,USA [7]Department of Medicine,Division of Allergy/Immunology/Rheumatology,University of Rochester Medical Center,Rochester,NY,USA [8]Department of Biomedical Engineering,University of Rochester,NY,USA [9]Department of Physiology/Pharmacology,University of Rochester Medical Center,Rochester,NY,USA

出　　处：《Bone Research》2023年第2期273-291,共19页骨研究（英文版）

基　　金：supported by awards from the National Institute of Health R21AR069789&R01 AG059775(to LX),R01 AG076786&R01 AG079556;The Henry and Marilyn Taub Foundation;the Edward P.Evans Foundation;the Mangurian Foundation;the National Aeronautics and Space Administration(to LMC);NIH R21 AR081050,R01 AR056702,P30 AR069655&P50 AR072000(to EMS);University of Rochester Aging Institute and the Dresner MDS foundation(to SY)。

摘　　要：Prior research establishing that bone interacts in coordination with the bone marrow microenvironment(BMME)to regulate hematopoietic homeostasis was largely based on analyses of individual bone-associated cell populations.Recent advances in intravital imaging has suggested that the expansion of hematopoietic stem cells(HSCs)and acute myeloid leukemia cells is restricted to bone marrow microdomains during a distinct stage of bone remodeling.These findings indicate that dynamic bone remodeling likely imposes additional heterogeneity within the BMME to yield differential clonal responses.A holistic understanding of the role of bone remodeling in regulating the stem cell niche and how these interactions are altered in age-related hematological malignancies will be critical to the development of novel interventions.To advance this understanding,herein,we provide a synopsis of the cellular and molecular constituents that participate in bone turnover and their known connections to the hematopoietic compartment.Specifically,we elaborate on the coupling between bone remodeling and the BMME in homeostasis and age-related hematological malignancies and after treatment with bone-targeting approaches.We then discuss unresolved questions and ambiguities that remain in the field.

关 键 词：REMODELING HOMEOSTASIS LIKELY 

分 类 号：R733[医药卫生—肿瘤]