lncRNA cytoskeleton regulator RNA(CYTOR):Diverse functions in metabolism,inflammation and tumorigenesis,and potential applications in precision oncology  

作　　者：Chunlin Ou Xiaoyun He Yong Liu Xin Zhang 

机构地区：[1]Department of Otolaryngology Head and Neck Surgery,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [2]Department of Pathology,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [3]Departments of Ultrasound Imaging,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [4]Otolaryngology Major Disease Research,Key Laboratory of Hunan Province,Changsha,Hunan 410008,China [5]Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province,Changsha,Hunan 410008,China [6]National Clinical Research Center for Geriatric Disorders (Xiangya Hospital),Changsha,Hunan 410008,China

出　　处：《Genes & Diseases》2023年第2期415-429,共15页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China(No.81974424,81874133,81772903 and 81903032);Natural Science Foundation of Hunan Province,China(No.2018JJ2630 and 2021JJ41013);the Huxiang Young Talent Project,China(No.2018RS3024);the China Postdoctoral Science Foundation(No.2020M672520);the Youth Fund of Xiangya Hospital,China(No.2018Q011).

摘　　要：Long non-coding RNAs(lncRNAs)are a novel class of non-coding RNA(ncRNA),that have been studied extensively in the field of tumor research in recent years.In the case of tumor-associated lncRNAs,lncRNA cytoskeleton regulator RNA(CYTOR)displays extensive functions in tumorigenesis,including invasion,metastasis,malignant proliferation,glycolysis,and inflammatory response.Moreover,the dysregulation of CYTOR is closely related to clinicopathological characteristics,such as tumor stage,lymph node metastasis and infiltration,and poor prognosis of tumor patients.In this review,we provide a novel strategy to summarize the biological functions and clinical value of CYTOR in tumors through an overview of the literature combined with gene set enrichment analysis.A deeper understanding of the role of CYTOR in tumorigenesis may provide new diagnostic,prognostic and therapeutic markers for human tumors.

关 键 词：CYTOR GSEA INFLAMMATION LncRNAs Therapy TUMORIGENESIS 

分 类 号：R730.2[医药卫生—肿瘤]