Angiogenic signaling pathways and anti-angiogenic therapy for cancer  

作　　者：Zhen-Ling Liu Huan-Huan Chen Li-Li Zheng Li-Ping Sun Lei Shi 

机构地区：[1]Department of Medicinal Chemistry,Jiangsu Key Laboratory of Drug Design and Optimization,China Pharmaceutical University,210009,Nanjing,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第6期2599-2637,共39页信号转导与靶向治疗（英文）

基　　金：supported by the National Natural Science Foundation of China(21102182);the Natural Science Foundation of Jiangsu Province(BK2012760,China);Fundamental Research Funds for the Central Universities(2632018ZD09,China);Excellent Science and Technology Innovation Team of Jiangsu Province Universities in 2015(China).

摘　　要：Angiogenesis,the formation of new blood vessels,is a complex and dynamic process regulated by various pro-and anti-angiogenic molecules,which plays a crucial role in tumor growth,invasion,and metastasis.With the advances in molecular and cellular biology,various biomolecules such as growth factors,chemokines,and adhesion factors involved in tumor angiogenesis has gradually been elucidated.Targeted therapeutic research based on these molecules has driven anti-angiogenic treatment to become a promising strategy in anti-tumor therapy.The most widely used anti-angiogenic agents include monoclonal antibodies and tyrosine kinase inhibitors(TKIs)targeting vascular endothelial growth factor(VEGF)pathway.However,the clinical benefit of this modality has still been limited due to several defects such as adverse events,acquired drug resistance,tumor recurrence,and lack of validated biomarkers,which impel further research on mechanisms of tumor angiogenesis,the development of multiple drugs and the combination therapy to figure out how to improve the therapeutic efficacy.Here,we broadly summarize various signaling pathways in tumor angiogenesis and discuss the development and current challenges of anti-angiogenic therapy.We also propose several new promising approaches to improve anti-angiogenic efficacy and provide a perspective for the development and research of anti-angiogenic therapy.

关 键 词：INVASION DRUGS METASTASIS 

分 类 号：R730.5[医药卫生—肿瘤]