Effects of acupotomy on the activity of osteoclasts and osteoblasts in the subchondral bone of rabbits with early and mid-stage knee osteoarthritis models  

作　　者：Mira Lee Yan Guo Xilin Chen Longfei Xing Wei Zhang Lia Chang Changqing Guo 

机构地区：[1]School of Acupuncture-Moxibustion and Tuin1,Beijing University of Chinese Medicine,Beijing 102488,China [2]Acupuncture and Moxibustion Department,Beijing Hospital of Traditional Chinese Medicine,Beijing 100010,China [3]Massage Department,Beijing University of Chinese Medicine Third Affiliated Hospital,Beijing 100029,China [4]Graduate School of Environmental Studies,Seoul National University,Seoul 08826,Republic of Korea

出　　处：《Journal of Traditional Chinese Medical Sciences》2023年第3期370-380,共11页中医科学杂志（英文）

基　　金：supported by the Beijing Municipal Natural Science Foundation(7192110)。

摘　　要：Objective:To investigate whether acupotomy could inhibit subchondral bone remodeling in knee osteoarthritis(KOA)rabbits by regulating the activity of osteoblasts and osteoclasts.Methods:KOA rabbits were prepared by immobilization for 6 and 9 weeks by Videman method.Nine groups of rabbits(control,6 weeks and 9 weeks model,6 weeks and 9 weeks acupotomy,6 weeks and 9 weeks electroacupuncture,and 6 weeks and 9 weeks drug groups)received acupotomy,electroacupuncture and risedronate sodium intervention,respectively,for 3 weeks.Results:Acupotomy can inhibit the activity of osteoclasts and osteoblasts in subchondral bone by reducing the proteins expression of cathepsin K(CK)and tartrate-resistant acid phosphatase(TRAP)and decreasing the proteins expression of osteocalcin(OCN)and alkaline phosphatase(ALP),to intercept the abnormal bone resorption and bone formation of subchondral bone in 6-week and 9-week immobilization-induced KOA rabbits.Conclusion:These findings indicated that acupotomy may be more advantageous than risedronate sodium intervention in modulating subchondral bone remodeling in KOA rabbits,especially in 9-week immobilization-induced KOA rabbits.

关 键 词：ACUPOTOMY Knee osteoarthritis OSTEOCLAST OSTEOBLAST Subchondral bone remodeling 

分 类 号：R245[医药卫生—针灸推拿学]