Advancements in understanding mechanisms of hepatocellular carcinoma radiosensitivity:A comprehensive review  

作　　者：Gaoyuan Yang Huamei Yan Yongchang Tang Feng Yuan Mingbo Cao Yupeng Ren Yuxuan Li Zhiwei He Xiaorui Su Zhicheng Yao Meihai Deng 

机构地区：[1]Department of Hepatobiliary Surgery,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China [2]Department of Radiation Oncology,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China [3]Department of General Surgery,Qilu Hospital,Shandong University,Jinan 250012,China [4]Department of General Surgery,The First Affiliated Hospital,Guangzhou Medical University,Guangzhou 511436,China [5]Department of Hepatobiliary and Pancreatic Surgery,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China

出　　处：《Chinese Journal of Cancer Research》2023年第3期266-282,共17页中国癌症研究（英文版）

基　　金：supported by the Science and Technology Plan Project of Guangzhou(No.202102010171);National Natural Science Foundation Cultivation Project of The Third Affiliated Hospital of Sun Yat-sen University(No.2020GZRPYMS11);Natural Science Foundation of Guangdong Province(No.2018A030313641);CSCO-Roche Joint Cancer Research Fund(No.Y-Roche2019/20041)。

摘　　要：Primary liver cancer is a significant health problem worldwide.Hepatocellular carcinoma(HCC)is the main pathological type of primary liver cancer,accounting for 75%-85%of cases.In recent years,radiotherapy has become an emerging treatment for HCC and is effective for various stages of HCC.However,radiosensitivity of liver cancer cells has a significant effect on the efficacy of radiotherapy and is regulated by various factors.How to increase radiosensitivity and improve the therapeutic effects of radiotherapy require further exploration.This review summarizes the recent research progress on the mechanisms affecting sensitivity to radiotherapy,including epigenetics,transportation and metabolism,regulated cell death pathways,the microenvironment,and redox status,as well as the effect of nanoparticles on the radiosensitivity of liver cancer.It is expected to provide more effective strategies and methods for clinical treatment of liver cancer by radiotherapy.

关 键 词：Hepatocellular carcinoma RADIOSENSITIVITY EPIGENETICS non-coding RNA cell death METABOLISM tumor microenvironment reactive oxygen species NANOPARTICLE 

分 类 号：R735.7[医药卫生—肿瘤]