Role of lipids in the control of autophagy and primary cilium signaling in neurons  

作　　者：María Paz Hernández-Cáceres Daniela Pinto-Nuñez Patricia Rivera Paulina Burgos Francisco Díaz-Castro Alfredo Criollo Maria Jose Yañez Eugenia Morselli 

机构地区：[1]Instituto de Investigación en Ciencias Odontológicas(ICOD),Facultad de Odontología,Universidad de Chile,Santiago,Chile [2]Department of Basic Sciences,Faculty of Medicine and Science,Universidad San Sebastián,Santiago,Chile [3]Physiology Department,Faculty of Biological Sciences,Pontificia Universidad Católica de Chile,Santiago,Chile [4]Advanced Center for Chronic Diseases(ACCDiS),Facultad de Ciencias Químicas y Farmacéuticas&Facultad de Medicina,Universidad de Chile,Santiago,Chile [5]Autophagy Research Center,Santiago,Chile

出　　处：《Neural Regeneration Research》2024年第2期264-271,共8页中国神经再生研究（英文版）

基　　金：funded by grants from Fondo Nacional de Desarrollo Científico y Tecnológico,FONDECYT 1200499 to EM,11200592 to MJY,1211329 to AC;by the ANID PIA ACT172066 to EM and AC;by the ANID postdoctoral fellowship 3210630 to MPHC;by the ANID doctoral fellowship 21230122 to DPN;by the ANID doctoral fellowship 21211189 to PR;by the ANID doctoral fellowship by the ANID doctoral fellowship 21210611 to FDC。

摘　　要：The brain is,after the adipose tissue,the organ with the greatest amount of lipids and diversity in their composition in the human body.In neurons,lipids are involved in signaling pathways controlling autophagy,a lysosome-dependent catabolic process essential for the maintenance of neuronal homeostasis and the function of the primary cilium,a cellular antenna that acts as a communication hub that transfers extracellular signals into intracellular responses required for neurogenesis and brain development.A crosstalk between primary cilia and autophagy has been established;however,its role in the control of neuronal activity and homeostasis is barely known.In this review,we briefly discuss the current knowledge regarding the role of autophagy and the primary cilium in neurons.Then we review the recent literature about specific lipid subclasses in the regulation of autophagy,in the control of primary cilium structure and its dependent cellular signaling in physiological and pathological conditions,specifically focusing on neurons,an area of research that could have major implications in neurodevelopment,energy homeostasis,and neurodegeneration.

关 键 词：autophagic flux CHOLESTEROL fatty acids GPCR lysosomal storage diseases NEURONS NPC1 PHOSPHOINOSITIDES primary cilium 

分 类 号：R338[医药卫生—人体生理学]