Membrane-bound O-acyltransferases(MBOATs)  

作　　者：Catherine C.Y.CHANG Jie SUN Ta-Yuan CHANG 

机构地区：[1]Department of Biochemistry,Dartmouth Medical School,Hanover,NH 03755 USA

出　　处：《Frontiers in Biology》2011年第3期177-182,共6页生物学前沿（英文版）

基　　金：supported by US NIH grants HL60306 and AG37609.

摘　　要：The MBOATenzyme family,identified in 2000,comprises 11 genes in the human genome that participate in a variety of biological processes.MBOAT enzymes contain multiple transmembrane domains and share two active site residues,histidine and asparagine.Several MBOAT members are drug targets for major human diseases,including atherosclerosis,obesity,Alzheimer disease,and viral infections.Here we review the historical aspects of MBOAT enzymes,classify them biochemically into 3 subgroups,and describe the essential features of each member.

关 键 词：cholesterol metabolism neutral lipid biosynthesis protein acylation membrane phospholipid remodeling ATHEROSCLEROSIS diabetes OBESITY cancer nutrient sensing 

分 类 号：R74[医药卫生—神经病学与精神病学]