遗传性口腔疾病相关牙齿替换障碍的早期治疗原则  

Early treatment principles of tooth replacement disorders associated with hereditary oral diseases

作　　者：郑树国[1] Zheng Shuguo(Department of Preventive Dentistry,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology,Beijing 100081,China)

机构地区：[1]北京大学口腔医学院·口腔医院口腔预防科、国家口腔医学中心、国家口腔疾病临床医学研究中心、口腔生物材料和数字诊疗装备国家工程研究中心、口腔数字医学北京市重点实验室,北京100081

出　　处：《中华口腔医学杂志》2023年第8期772-780,共9页Chinese Journal of Stomatology

基　　金：国家自然科学基金(81771053,81070815);北京市科学技术委员会首都临床特色应用研究基金(Z121107001012029)。

摘　　要：牙齿替换障碍表现为乳牙脱落异常及恒牙萌出障碍。涉及多颗牙齿替换障碍的遗传性疾病主要包括颅骨锁骨发育不全、骨硬化症和加德纳综合征(Gardner syndrome)3种。这3种疾病较罕见,治疗难度大,治疗原则存在较大差异。本文以这3种遗传性疾病为例,阐述遗传性口腔疾病相关牙齿替换障碍的临床表现、早期治疗原则,以及口腔医师在多种遗传性疾病早期诊断中的重要作用。Tooth replacement disorders are characterized by retention of deciduous teeth and abnormalities in permanent teeth eruption.Hereditary disorders with multiple teeth involved include cleidocranial dysplasia,osteopetrosis and Gardner syndrome.These rare diseases have great difficulty in treatment with various principles reported.This article focused on clinical manifestations and early treatment principles of these hereditary disorders,as well as the important role of dentists in early diagnosis of these diseases.

关 键 词：骨硬化症 牙齿替换障碍 遗传性口腔疾病 颅骨锁骨发育不全 GARDNER综合征 

分 类 号：R781[医药卫生—口腔医学]