植物化学成分对变异链球菌生物被膜的抑制机制研究进展  

Advance on inhibition mechanism of phytochemicals on Streptococcus mutans biofilm

作　　者：王琳[1] 武雨伦 曹学丽[1] WANG Lin;WU Yulun;CAO Xueli(Beijing Advanced Innovation Centre for Food Nutrition and Human Health,School of Light Industry,Beijing Technology and Business University,Beijing 100048,China)

机构地区：[1]北京工商大学轻工科学技术学院,北京食品营养与人类健康高精尖创新中心,北京100048

出　　处：《中国酿造》2023年第8期7-13,共7页China Brewing

基　　金：“十三五”国家重点研发计划课题(2018YFC1604306)。

摘　　要：变异链球菌(Streptococcus mutans)是致龋关键致病菌,能黏附于牙齿表面并形成生物被膜。近年来,植物化学成分抑制生物被膜的功能广受关注,是挖掘新型生物被膜抑制剂的重要来源。该文总结变异链球菌菌体表面黏附过程、双组分调控系统、群体感应系统对生物被膜的调控机制。以生物被膜的形成机制为基础,探讨黄酮、多酚、萜类等植物性化学成分对变异链球菌生物被膜的抑制机制,抑制作用主要体现在:抑制双组分调控系统、群体感应系统关键酶活力;改变菌体表面特性;抑菌作用;破坏生物被膜分子间作用力。该文为开发抗变异链球菌生物被膜的植物源性制剂提供理论参考。Streptococcus mutans is the key pathogen causing caries,which adhere to the tooth surface and forming biofilm.Recent years,more attention has been paid to the inhibition of biofilm by phytochemicals,which are important sources for exploring new biofilm inhibitors.In this paper,the regulatory mechanism of surface adhesion process,two-component regulation system and quorum sensing system of S.mutans on biofilm were summarized.Based on the mechanism of biofilm formation,the inhibition mechanism of phytochemical components such as flavonoids,polyphenols and terpenes on S.mutans biofilm was investigated.The inhibitory effects were mainly reflected in:inhibiting the activity of key enzymes in the two-component regulatory system and quorum sensing system,change the surface characteristics of bacteria,bacteriostatic effect,and destruction of biofilm intermolecular forces.The review provided theoretical reference for the development of phytochemicals resistant to S.mutans biofilm.

关 键 词：变异链球菌 生物被膜 抑制机制 群体感应系统 植物化学成分 

分 类 号：TS264.2[轻工技术与工程—发酵工程]