硒和硒蛋白与宿主肠道健康的互作调节机制  

Role of selenium and selenoprotein in gut health

作　　者：何羿文 黄乐 周锡红[2] 印遇龙[2,3] 何流琴 HE YiWen;HUANG Le;ZHOU XiHong;YIN YuLong;HE LiuQin(Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation,Hunan International Joint Laboratory of Animal Intestinal Ecology and Health,College of Life Sciences,Hunan Normal University,Changsha 410081,China;Hunan Provincial Key Laboratory of Animal Nutrition Physiology and Metabolism Process,Key Laboratory of Agro-Ecological Processes in Subtropical Region,Institute of Subtropical Agriculture,Chinese Academy of Sciences,Changsha 410125,China;Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China)

机构地区：[1]湖南师范大学生命科学学院,动物肠道功能调控湖南省重点实验室,湖南省动物肠道生态与健康国际联合实验室,长沙410081 [2]中国科学院亚热带农业生态研究所,亚热带农业生态过程重点实验室,动物营养生理与代谢过程湖南省重点实验室,长沙410125 [3]中国科学院天津工业生物技术研究所,天津300308

出　　处：《中国科学：生命科学》2023年第8期1055-1066,共12页Scientia Sinica(Vitae)

基　　金：国家自然科学基金(批准号:32172755,3210099);湖南省“湖湘青年英才”项目(批准号:2020RC3052);国家级大学生创新创业训练计划支持项目(批准号:202210542036);天津市合成生物技术创新能力提升项目(批准号:TSBICIP-CXRC-038);长春市院科技创新合作专项(批准号:21SH19)资助。

摘　　要：硒是生物体必需的微量元素之一,在体内合成为硒蛋白,参与抗氧化和免疫应答等众多生理机能的调控.近期研究表明,硒和硒蛋白可能与宿主肠道微生物、抗氧化系统和免疫因子存在互作调节肠道稳态的功能,进而起到预防和治疗肠道疾病的作用.本文综述了硒在肠道中的吸收和硒蛋白的合成及功能,重点解析了硒和硒蛋白与肠道微生物、肠道氧化应激和肠道免疫间的互作调节机制及其在肠癌中的潜在作用,以期为硒用于预防或治疗肠道疾病提供新的思路和依据.Selenium,one of the essential trace elements for living organisms,participates in the regulation of physiological functions such as anti-oxidation and immune response when converted into selenoproteins.Recent studies have shown that selenium and selenoproteins may interact with host intestinal microbiota,antioxidant system,and immune factors to regulate intestinal homeostasis,therefore played a crucial role in the prevention and treatment of intestinal diseases.In this review,the absorption of selenium in the intestinal tract and the synthesis and function of selenoproteins were briefly introduced,the interactive regulation mechanism of selenium and selenoproteins with intestinal microbiota,intestinal oxidative stress,and intestinal immunity were discussed,and the potential role of selenium in intestinal cancer were analyzed,which provided new ideas and basis for the use of selenium in the prevention or treatment of intestinal diseases.

关 键 词：硒 硒蛋白 肠道微生物 氧化应激 免疫 癌症 

分 类 号：R735.3[医药卫生—肿瘤]