活化蛋白激酶C受体1在宫颈鳞状细胞癌中的表达及其与PI3K/Akt/mTOR信号转导通路关系的研究  

Expression of Activated Protein Kinase C Receptor 1 in Cervical Squamous Cell Carcinoma and its Relationship with PI3K/Akt/mTOR Signal Transduction Pathway

作　　者：王瑞才[1] 朱建友[1] WANG Rui-cai;ZHU Jian-you(Department of Pathology,Zibo Municipal Hospital,Affiliated to Binzhou Medical College,Zibo 255400,Shandong,China)

机构地区：[1]滨州医学院附属淄博市市立医院病理科,山东淄博255400

出　　处：《医学信息》2023年第17期107-110,共4页Journal of Medical Information

摘　　要：目的探讨PI3K/Akt/mTOR信号转导通路蛋白及RACK1在宫颈鳞状细胞癌中的表达及意义,以及与临床病理参数间的关系。方法选取2014年1月-2020年12月淄博市市立医院59例宫颈鳞癌组织及45例非肿瘤宫颈组织,用链霉亲和素-过氧化物酶免疫组化染色检测RACK1和PI3K、Akt、mTOR蛋白的表达。结果RACK1在宫颈鳞癌组织中的阳性表达率低于非肿瘤宫颈组织(P<0.05);PI3K、Akt、mTOR在宫颈鳞癌组织中的阳性表达率高于非肿瘤宫颈组织(P<0.05);PI3K和mTOR在宫颈鳞癌中的表达与淋巴结转移及TNM分期相关(P<0.05)。结论宫颈鳞癌组织中RACK1表达下调,PI3K、Akt、mTOR表达上调。PI3K/Akt/mTOR信号转导通路可能参加了宫颈鳞癌的发生发展过程。Objective To investigate the expression and significance of PI3K/Akt/mTOR signal transduction pathway protein and RACK1 in cervical squamous cell carcinoma,and the relationship with clinicopathological parameters.Methods From January 2014 to December 2020,59 cases of cervical squamous cell carcinoma and 45 cases of non-tumor cervical tissues were selected from Zibo Municipal Hospital were collected.The expression of RACK1,PI3K,Akt and mTOR proteins was detected by streptavidin-peroxidase immunohistochemical staining.Results The positive expression rate of RACK1 in cervical squamous cell carcinoma was lower than that in non-tumor cervical tissues(P<0.05).The positive expression rates of PI3K,Akt and mTOR in cervical squamous cell carcinoma were higher than those in non-tumor cervical tissues(P<0.05).The expression of PI3K and mTOR in cervical squamous cell carcinoma was related to lymph node metastasis and TNM stage(P<0.05).Conclusion The expression of RACK1 is down-regulated and the expression of PI3K,Akt and mTOR is up-regulated in cervical squamous cell carcinoma.PI3K/Akt/mTOR signal transduction pathway may be involved in the occurrence and development of cervical squamous cell carcinoma.

关 键 词：RACK1 PI3K Akt MTOR 宫颈鳞癌 

分 类 号：R737.33[医药卫生—肿瘤]