Hepatocellular carcinoma surveillance:current practice and future directions  

作　　者：Joseph CAhn Yi-Te Lee Vatche GAgopian Yazhen Zhu Sungyong You Hsian-Rong Tseng Ju Dong Yang 

机构地区：[1]Division of Gastroenterology and Hepatology,Mayo Clinic,Rochester,MN 55905,USA [2]California NanoSystems Institute,Crump Institute for Molecular Imaging,University of California,Los Angeles,CA 90095,USA [3]Department of Molecular and Medical Pharmacology,University of California,Los Angeles,CA 90095,USA [4]Department of Surgery,University of California,Los Angeles,CA 90095,USA [5]Jonsson Comprehensive Cancer Center,University of California,Los Angeles,CA 90048,USA [6]Samuel Oschin Comprehensive Cancer Institute,Cedars-Sinai Medical Center,Los Angeles,CA 90048,USA [7]Departments of Surgery,Cedars-Sinai Medical Center,Los Angeles,CA 90048,USA [8]Karsh Division of Gastroenterology and Hepatology,Cedars-Sinai Medical Center,Los Angeles,CA 90048,USA [9]Comprehensive Transplant Center Cedars-Sinai Medical Center,Los Angeles,CA 90048,USA

出　　处：《Hepatoma Research》2022年第1期157-168,共12页肝癌研究（英文版）

基　　金：funded by the American College of Gastroenterology,grant name“Junior Faculty Development Award”;United States Department of Defense,grant number CA191051;National Institutes of Health,grant number R01CA246304,R01CA253651,R01CA255727,R21CA235340,and R21CA240887.

摘　　要：Hepatocellular carcinoma(HCC)is among the leading causes of cancer incidence and mortality worldwide.Surveillance of individuals with cirrhosis or other conditions that confer a high risk of HCC development is essential for early detection and improved overall survival.Biannual ultrasonography with or without alpha-fetoprotein is widely recommended as the standard method for HCC surveillance,but it has limited sensitivity in early disease and may be inadequate in certain individuals.This review article will provide a comprehensive overview of the current landscape of HCC surveillance,including the rationale and indications for HCC surveillance,standard methods for HCC surveillance,and their strengths/limitations.Alternative surveillance methods such as the role of cross-sectional imaging,emerging circulating biomarkers,as well as the problem of under-utilization of HCC surveillance and surveillance-related harms will also be discussed in this review.

关 键 词：Hepatocellular carcinoma SURVEILLANCE CIRRHOSIS hepatitis B virus ALPHA-FETOPROTEIN liquid biopsy under-utilization 

分 类 号：R73[医药卫生—肿瘤]