青少年重性抑郁症患者脑功能网络拓扑属性研究  

Topological properties of brain functional networks in adolescents with major depressive disorder

作　　者：曹江慧 赵宗海 宋萍 吴宝林 王勇 刘广志 Cao Jianghui;Zhao Zonghai;Song Ping;Wu Baolin;Wang Yong;Liu Guangzhi(Department of Radiology,Xiangyang No.1 Hospital Affilated to Hubei University of Medicince,Xiangyang 441000,China;Department of Radiology,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Neurology,Xiangyang No.1 Hospital Affilated to Hubei University of Medicince,Xiangyang 441000,China)

机构地区：[1]湖北医药学院附属襄阳市第一人民医院放射科,襄阳441000 [2]四川大学华西医院放射科,成都610041 [3]湖北医药学院附属襄阳市第一人民医院神经内科,襄阳441000

出　　处：《中华神经医学杂志》2023年第6期559-565,共7页Chinese Journal of Neuromedicine

摘　　要：目的探讨首发未用药青少年重性抑郁症(MDD)患者脑功能网络的拓扑属性改变。方法选择湖北医药学院附属襄阳市第一人民医院神经内科门诊自2022年1月至2023年1月收治的76例首发未用药青少年MDD患者(MDD组)为研究对象,另选择同期广告招募的66例与MDD组患者性别、年龄相匹配的健康志愿者为对照组。对所有受试者行静息态功能磁共振成像(fMRI)检查,在每个被试下构建全脑功能网络,应用图论方法分析2组成员间脑功能网络全局拓扑指标(全局效率、局部效率、聚类系数、特征路径长度、标准化聚类系数、标准化特征路径长度、小世界属性)及节点拓扑指标(节点效率、节点度和节点介数)的差异,并采用基于网络的统计方法检验全脑网络功能连接强度的组间差异。结果MDD组患者和对照组成员的脑功能网络均显示出小世界属性。与对照组相比,MDD组患者脑功能网络的全局效率明显升高[0.129(0.124,0.132)vs.0.131(0.128,0.133)],聚类系数、特征路径长度明显降低[0.143(0.139,0.146)vs.0.139(0.135,0.144);0.457(0.446,0.734)vs.0.451(0.440,0.463)],以及右侧顶下小叶、双侧尾状核及双侧丘脑的节点中心性明显升高,差异均有统计学意义(P<0.05,FDR校正)。MDD组患者的眶额回-颞叶及前扣带回-边缘系统-颞叶环路的功能连接强度较对照组显著减弱。结论青少年MDD患者脑功能网络的拓扑属性存在异常,其可能是青少年始发抑郁症的潜在神经病理基础。Objective To investigate the topological properties of whole-brain functional networks in first-episode drug-naïve adolescents with major depressive disorder(MDD).Methods Seventy-six first-episode drug-naïve adolescents with MDD admitted to Department of Neurology,Xiangyang No.1 Hospital Affilated to Hubei University of Medicince from January 2022 to January 2023 were selected as study subjects;66 gender-and age-matched healthy controls(HCs)were recruited via advertisement.All subjects underwent resting-state functional MRI.The whole-brain functional networks were constructed for each subject;and then,the global topological metrics(global efficiency,local efficiency,clustering coefficient,characteristic path length,normalized clustering coefficient,normalized characteristic path length,and small-worldness properties)and local topological metrics(nodal degree centrality,nodal efficiency and nodal betweenness centrality)of the functional brain networks were analyzed between the two groups using graph-theory methods.Network-based statistics were used to examine between-group differences in functional connectivity strength of whole brain networks.Results Small-worldness properties were demonstrated in both MDD group and HC group.MDD patients showed significantly higher global efficiency(0.129[0.124,0.132]vs.0.131[0.128,0.133]),significantly lower clustering coefficient and characteristic path length(0.143[0.139,0.146]vs.0.139[0.135,0.144];0.457[0.446,0.734]vs.0.451[0.440,0.463]),and significantly increased nodal centralities in the right inferior parietal lobule,bilateral caudate nucleus and bilateral thalamus of brain functional networks compared with HCs(P<0.05,FDR-corrected).Compared with HCs,MDD patients exhibited obviously lower functional connectivity strength in the orbitofrontal-temporal and anterior cingulate-limbic-temporal circuits.Conclusion Abnormal alterations of topological properties of the brain functional networks are found in adolescents with MDD,which may be the underlying neuropathologic basis

关 键 词：重性抑郁症 青少年 静息态功能磁共振成像 脑功能网络 拓扑属性 图论 

分 类 号：R749.4[医药卫生—神经病学与精神病学]