乳杆菌胞外多糖合成基因簇及构效关系  

Lactobacillus exopolysaccharide:gene clusters for synthesis and structure-activity relationship

作　　者：石金铭 陈秋羽 刘昭曦 刘双江 陈敏 SHI Jinming;CHEN Qiuyu;LIU Zhaoxi;LIU Shuangjiang;CHEN Min(State Key Laboratory of Microbial Technology,Microbial Technology Institute,Shandong University,Qingdao 266237,Shandong,China)

机构地区：[1]山东大学微生物技术研究院微生物国家重点实验室,山东青岛266237

出　　处：《微生物学报》2023年第9期3482-3499,共18页Acta Microbiologica Sinica

基　　金：国家重点研发计划(2022YFA1304103);国家自然科学基金(32070921);泰山产业领军人才工程专项经费(tscy20200221);山东省重点研发计划(2020CXGC010601)。

摘　　要：肠道菌群稳态对维护人体的健康具有至关重要的作用。作为肠道天然微生物群“守卫兵”,益生菌参与改善体内微生态平衡。乳杆菌(Lactobacillus)是一种肠道益生菌的代表,其合成的胞外多糖(exopolysaccharide,EPS)既可通过增益肠道内其他益生菌的生长来优化肠道微生态,还具有抗肿瘤、抗氧化、降胆固醇、降血压和增强机体免疫力等益生功能。本文对近年来乳杆菌胞外多糖的遗传、生物学活性、构效关系等方面的研究进展,进行综述和展望。Intestinal microflora homeostasis plays a crucial role in maintaining human health.As a guard of the natural intestinal microflora,probiotics improve the microecological balance in the host.Lactobacillus is a representative of intestinal probiotics.The exopolysaccharide(EPS)synthesized by Lactobacillus can optimize the intestinal microecology by promoting the growth of other probiotics in the intestine.Moreover,EPS is praised for anti-tumor,antioxidant,cholesterol-lowering,blood pressure-lowering,and immunity-enhancing activities.This article reviews the research progress in the genetics,biological activities,structure-activity relationship of Lactobacillus EPS in recent years.

关 键 词：乳杆菌 胞外多糖 基因簇 多糖结构 构效关系 

分 类 号：Q939.1[生物学—微生物学]