Role of lysosomal trafficking regulator in autophagic lysosome reformation in neurons:a disease perspective  

作　　者：Prashant Sharma Jenny Serra-Vinardell Wendy J.Introne May Christine V.Malicdan 

机构地区：[1]NIH Undiagnosed Diseases Program,Common Fund,Office of the Director,National Institutes of Health,Bethesda,MD,USA [2]Human Biochemical Genetics Section,Medical Genetics Branch,National Human Genome Research Institute,National Institutes of Health,Bethesda,MD,USA(Serra-Vinardell J,Introne)

出　　处：《Neural Regeneration Research》2024年第5期957-958,共2页中国神经再生研究（英文版）

摘　　要：Lysosomes are discrete organelles that act as recycling centers for extracellular and intracellular materials,playing a pivotal role in maintaining cellular homeostasis.Their acidic environment,maintained by numerous hydrolytic enzymes,facilitates substrate degradation.Dysfunction in lysosomal processes can lead to abnormal substrate degradation,significantly impacting cellular homeostasis.High energy-demanding cells,such as post-mitotic neurons,are especially vulnerable to these changes,often resulting in neurological diseases.Autophagy,a conserved catabolic process,requires extensive lysosomal utilization.It plays a key role in removing unnecessary intracellular components,ensuring cellular homeostasis,and promoting cell survival during stress conditions such as starvation,infection,or cellular damage.

关 键 词：HOMEOSTASIS LYSOSOMAL removing 

分 类 号：R741[医药卫生—神经病学与精神病学]