火麻仁油藻油组合物辅助降血脂功能人体试食试验  

Experimental study on the assisted hypolipidemic function of the mixture between hemp seed oil and algae oil in the human body

作　　者：陈则华 李泓颖 周勇 李文治 CHEN Zehua;LI Hongying;ZHOU Yong;LI Wenzhi(Infinitus〔China〕Company Ltd.,Guangzhou,Guangdong 510405,China;Healthy-Star Bio-Tech R&D Ltd.,Shanghai 200335,China;South China University of Technology,School of Food Science and Engineering,Guangzhou,Guangdong 510641,China)

机构地区：[1]无限极〔中国〕有限公司,广东广州510405 [2]健士星生物技术研发〔上海〕有限公司,上海200335 [3]华南理工大学食品科学与工程学院,广东广州510641

出　　处：《食品与机械》2023年第8期147-154,共8页Food and Machinery

基　　金：广东省科技创新战略专项项目(编号:江科2021[182]号)。

摘　　要：目的:探讨火麻仁油藻油组合物对人体降血脂的功能作用。方法:选择113人随机分为对照组和试食组两组,试食组连续服用火麻仁油藻油组合物90 d,对照组以安慰剂代替。检测试食前后两组的血清总胆固醇水平(TC)、甘油三酯水平(TG)、高密度脂蛋白胆固醇(HDL-C)水平、低密度脂蛋白胆固醇(LDL-C)水平及生理生化指标,试食组在试食前后检测肝胆彩超、颈动脉斑块彩超、空腹血糖、糖化血红蛋白、炎症指标肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)和抗氧化指标超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)。结果:试食组实施前后自身比较及试食组与对照组组间比较显示,TC、TG、LDL-C含量差异均具有统计学意义,试食后显著低于试食前(P<0.01),试食组显著低于对照组(P<0.05);试食组的总有效率显著高于对照组(P<0.05)。试食组试食后,糖化血红蛋白水平下降(P<0.05),IL-6水平显著降低(P<0.05),SOD和GSH-Px活性升高(P<0.01),颈动脉斑块和脂肪肝改善率分别为33.3%,39.3%。肝、肾功能等检查结果未发现异常。结论:火麻仁油藻油组合物具有良好的降血脂功能,可能与抗炎、抗氧化作用相关,且具有较高的安全性。Objective:To study the effect of hemp seed and algal oil mixture in lowering blood lipids,and provide the theoretical basis for the utilization of hemp seed and algal oil mixture in food.Methods:113 hyperlipidemia adult volunteers were selected and randomly divided into two groups,namely the experiment group and the control group.The subjects in the experiment group were given gelatinized confections for 90 days,while subjects in the control group were given a placebo.The levels of Serum total cholesterol(TC),Triglyceride(TG),High-density lipoprotein cholesterol(HDL-C),Low-density lipoprotein cholesterol(LDL-C)and physiological and biochemical parameters were measured before and after trial.For the experiment group,hepatobiliary ultrasonography,carotid plaque ultrasonography,fasting blood glucose,glycosylated hemoglobin,inflammatory indicators tumor necrosis factor-α,interleukin-6,C-reactive protein and antioxidant indicators superoxide dismutase,malondialdehyde,glutathione peroxidase were detected.Results:At the end of the human trial,compared with the control group,serum TC,TG and LDL-C levels of the experiment group decreased significantly(P<0.05).And the rate of effective lowering lipid level is 30.4%in the experiment group at the end of trials.No abnormal effect was observed in liver function,renal function and hematological examination.In the experiment group,the levels of hBA1c and IL-6 were decreased(P<0.05),SOD and GSH-Px activities increased(P<0.01),the improvement rate of carotid plaque and fatty liver was 33.3%and 39.3%,respectively.Conclusion:Hemp seed and algal oil mixture tested in the study have a good function of lowering blood lipid in humans with an acceptable safety profile,which may be related to anti-inflammatory and antioxidant effects.

关 键 词：Ω-3多不饱和脂肪酸 火麻仁油 DHA藻油 降血脂 人体试食试验 

分 类 号：TS225.1[轻工技术与工程—粮食、油脂及植物蛋白工程]