The role of microglia in depression  

作　　者：Lester Raymundo Dominguez Huarcaya María Fernanda Dominguez Ríos 

机构地区：[1]Faculty of Pharmacy and Biochemistry,National University of San Marcos,Lima 01,Peru [2]Faculty of Psychology,Pontifical Catholic University of Peru,1801 Universitaria Avenue,San Miguel,Lima 32,Peru.

出　　处：《Microenvironment & Microecology Research》2023年第3期10-15,共6页微环境与微生态学研究（英文）

摘　　要：According to studies,neuroinflammation is increasingly being linked to the development of major depressive disorder(MDD).In response to inflammatory stimuli,brain microglia,which are immune cells,can change into reactive states.Because of this,microglia play an essentiall role in the early stages of neuroinflammation.Experiments have shown that microglia are able to detect infected or damaged cells,which then activates a cytotoxic response that further exacerbates the harm to brain cells.It has been proven that microglia are quite good at recognizing infections and damaged cells.Microglia,on the other hand,have been found to respond in a number of ways to injury and may even help regenerate damaged tissues.Chronic activation of microglia has been observed in persons with MDD.Deficits in neuroplasticity have been linked to depression,and recent studies show that this may be related to changes in microglia shape and function brought on by either excessive inflammatory activity or the natural aging process.Changing the phenotype of microglia by regulation of inflammatory pathways may be necessary for harnessing neuroinflammation in MDD.Recent research has linked several microglial phenotypes to individual metabolic pathways,showing that energy metabolism plays a pivotal role in coordinating microglial activity.In this study,we investigate whether or not traditional pro-inflammatory,anti-inflammatory,and metabolic pathways in microglia can be used as novel therapeutic routes for regulating neuroinflammation in brain diseases.The focus of this essay is on MDD,although we will also discuss related mental health issues.

关 键 词：anti-inflammatory pathway major depressive disorder metabolic pathway MICROGLIA microglial pathways as therapeutic targets NEUROINFLAMMATION pro-inflammatory pathway 

分 类 号：R74[医药卫生—神经病学与精神病学]