New Neuraminidase Inhibitory Alkaloids from the Mangrove Soil-Derived Fungus Arthrinium sp.SCSIO 41305  

作　　者：HU Yiwei ZHAO Kai ZHU Junheng QI Xin CHEN Weihao SONG Yingying PANG Xiaoyan LIU Yonghong WANG Junfeng 

机构地区：[1]CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology,Guangdong Key Laboratory of Marine Materia Medica,Innovation Academy of South China Sea Ecology and Environmental Engineering,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China [2]Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou),Guangzhou 511458,China [3]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Journal of Ocean University of China》2023年第5期1446-1451,共6页中国海洋大学学报（英文版）

基　　金：the Guangdong Basic and Applied Basic Research Foundation(Nos.2021 A1515011523,2021B1515120046);the Guangdong MEPP Funds(No.GDNRC[2021]48);the Finance Science and Technology Project of Hainan Province(No.ZDKJ202018);National Natural Science Foundation of China(No.41776169)。

摘　　要：New alkaloid,(E)-2-(hydroxyimino)-4-methylpentanamide(1)and a new cyclopentano[b]pyridine,4-hydroxy-7-methyl-6,7-dihydro-5H-cyclopenta[c]pyridin-5-one(2),together with ten known compounds(3–12)were isolated from the mangrove soil-derived fungus Arthrinium sp.SCSIO 41305.Extensive spectroscopic analysis and X-Ray crystallographic analysis were used to elucidate the structure of(E)-2-(hydroxyimino)-4-methylpentanamide(1),including its absolute configuration.All the isolated compounds(1–12)were evaluated for their antimicrobial and enzyme inhibitory activities against acetylcholinesterase(ACh E),neuraminidase(NAs),and phosphatidylinositol 3-kinase(PI3K).Among them,compounds 1 and 3 exhibited strong neuraminidase inhibitory activity with IC_(50)values of 12.04,1.92μmol L^(-1)(IC_(50)20μmol L^(-1)for oseltamivir acid),while compounds 5,6,8,and 10showed moderate neuraminidase inhibitory activity,and compounds 6–10 displayed weak enzyme inhibitory activities against PI3K.

关 键 词：Arthrinium ALKALOID pyridine NEURAMINIDASE ACETYLCHOLINESTERASE 

分 类 号：Q93[生物学—微生物学]