the Guangdong Basic and Applied Basic Research Foundation(Nos.2021 A1515011523,2021B1515120046);the Guangdong MEPP Funds(No.GDNRC[2021]48);the Finance Science and Technology Project of Hainan Province(No.ZDKJ202018);National Natural Science Foundation of China(No.41776169)。
New alkaloid,(E)-2-(hydroxyimino)-4-methylpentanamide(1)and a new cyclopentano[b]pyridine,4-hydroxy-7-methyl-6,7-dihydro-5H-cyclopenta[c]pyridin-5-one(2),together with ten known compounds(3–12)were isolated from the ...
supported by the National Research Foundation of Korea(NRF)grant funded 2021R1A2C2094436 and 2020R1C1C1006749;the Korea Institute of Oriental Medicine grant number KSN2022230 provided by the Ministry of Science and ICT,Korea。
The development of drug-resistant influenza and new pathogenic virus strains underscores the need for antiviral therapeutics.Currently,neuraminidase(NA)inhibitors are commonly used antiviral drugs approved by the US F...
Natural Science Foundation of China(Grant No.81773583);Tackling Key Research Project for New Corona Virus Prevention and Treatment of Tianjin University of Science&Technology(Grant No.2020STCV0019)。
In the present study,we developed a novel colorimetric strategy for the visible rapid detection of the influenza virus based on the unique optical properties of gold nanorods.Specifically,lipoic acid-modified Oseltami...
the Research Foundation of Zhejiang Health,No.2020RC061。
BACKGROUND Type 1 sialidosis,also known as cherry-red spot-myoclonus syndrome,is a rare autosomal recessive lysosomal storage disorder presenting in the second decade of life.The most common symptoms are myoclonus,ata...
National Nature Science Foundation of China (Grant No. 81241114);Basic Research Project of Logistics University of PAP (Grant No. WHJ201401);Fund for Scientific Research and Innovation Team of Logistics University of PAP。
Neuraminidase(NA) plays a biologically vital role in the replication of influenza virus, and NA inhibitors(NAIs) are most widely used in the clinical anti-flu therapy. NA of 2009 H1 N1 influenza virus(09 N1) possesses...
OBJECTIVE Sheng Jiang San(SJS),a multi-herb formulation,is used in treating high fever,thirsty and anxiety in ancient China and it is sometimes used to treat seasonal influenza in modern.However,there is no evidenceba...
the Hunan Provincial Natural Science Foundation,China(No.2019JJ40030);the National Natural Science Foundation of China(No.81673480).
Twenty-seven novel chaicone derivatives were designed and synthesized as neuraniinidase(NA) inhibitors. A concise suitable synthetic strategy was employed in the target compounds? synthesis with relatively high yields...
Project supported by the National Natural Science Foundation of China(Grant Nos.11374237 and 11504287);Fundamental Research Funds for the Central Universities,China,China Postdoctoral Science Foundation(Grant No.2017M613147);Shaanxi Province Postdoctoral Science Foundation,China
Neuraminidase (NA), a major surface glycoprotein of influenza virus with well-defined active sites, is an ideal plat- form for the development of antiviral drugs. However, a growing number of NA mutations have drug ...
financially supported by the National Natural Science Foundation of China(Nos.21402140,21502139);Shenzhen Peacock Plan(No. KQTD2016053114253158);Natural Science Foundation of Tianjin City(No. 16JCTPJC46000);Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education;Tianjin Key Lab of Industrial Microbiology(No. 2015IM107);Youth Innovation Research Foundation of Tianjin University of Science and Technology(No.2016LG08)
We report the synthesis of pseudo triazole-sialoside protein conjugates of various valency that are resistant to neuraminidase for the adsorption of influenza viruses. The glycotriazole monomer bearing an amine-functi...
supported by the National Natural Science Foundation of China(Nos.81274026,81403126,81330090,81573676)
Anti-influenza Chinese herbal medicines(anti-flu CHMs) have advantages in preventing and treating influenza virus infection. Despite various data on antiviral activities of some anti-flu CHMs have been reported, most ...