NEURAMINIDASE

作品数:43被引量:72H指数:5
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相关领域:医药卫生农业科学更多>>
相关作者:魏来高燕杨霞陈美芳郭晓琳更多>>
相关机构:北京大学广东省疾病预防控制中心中山大学更多>>
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相关基金:国家自然科学基金北京市自然科学基金教育部“优秀青年教师资助计划”国家高技术研究发展计划更多>>
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New Neuraminidase Inhibitory Alkaloids from the Mangrove Soil-Derived Fungus Arthrinium sp.SCSIO 41305
《Journal of Ocean University of China》2023年第5期1446-1451,共6页HU Yiwei ZHAO Kai ZHU Junheng QI Xin CHEN Weihao SONG Yingying PANG Xiaoyan LIU Yonghong WANG Junfeng 
the Guangdong Basic and Applied Basic Research Foundation(Nos.2021 A1515011523,2021B1515120046);the Guangdong MEPP Funds(No.GDNRC[2021]48);the Finance Science and Technology Project of Hainan Province(No.ZDKJ202018);National Natural Science Foundation of China(No.41776169)。
New alkaloid,(E)-2-(hydroxyimino)-4-methylpentanamide(1)and a new cyclopentano[b]pyridine,4-hydroxy-7-methyl-6,7-dihydro-5H-cyclopenta[c]pyridin-5-one(2),together with ten known compounds(3–12)were isolated from the ...
关键词:Arthrinium ALKALOID pyridine NEURAMINIDASE ACETYLCHOLINESTERASE 
Vitisin B inhibits influenza A virus replication by multi-targeting neuraminidase and virusinduced oxidative stress被引量:3
《Acta Pharmaceutica Sinica B》2023年第1期174-191,共18页Eun-Bin Kwon Wei Li Young Soo Kim Buyun Kim Hwan-Suck Chung Younghoon Go Hyun-Jeong Ko Jae-Hyoung Song Young Ho Kim Chun Whan Choi Jang-Gi Choi 
supported by the National Research Foundation of Korea(NRF)grant funded 2021R1A2C2094436 and 2020R1C1C1006749;the Korea Institute of Oriental Medicine grant number KSN2022230 provided by the Ministry of Science and ICT,Korea。
The development of drug-resistant influenza and new pathogenic virus strains underscores the need for antiviral therapeutics.Currently,neuraminidase(NA)inhibitors are commonly used antiviral drugs approved by the US F...
关键词:INFLUENZA Vitisin B Vitis vinifera L. NEURAMINIDASE Reactive oxygen species NF-κB Multi-targeting Nrf2 G6PD 
Oseltamivir decorated gold nanorods for visible rapid detection of influenza virus
《Journal of Chinese Pharmaceutical Sciences》2022年第7期491-498,共8页Wenbin Liu Dong Liu Xue Wang Zhaoliang Yang Yun He Yang Yang 
Natural Science Foundation of China(Grant No.81773583);Tackling Key Research Project for New Corona Virus Prevention and Treatment of Tianjin University of Science&Technology(Grant No.2020STCV0019)。
In the present study,we developed a novel colorimetric strategy for the visible rapid detection of the influenza virus based on the unique optical properties of gold nanorods.Specifically,lipoic acid-modified Oseltami...
关键词:Gold nanorods OSELTAMIVIR Influenza virus NEURAMINIDASE Visible detection 
Compound heterozygous mutations in the neuraminidase 1 gene in type 1 sialidosis: A case report and review of literature被引量:4
《World Journal of Clinical Cases》2021年第3期623-631,共9页Lan-Xiao Cao Ying Liu Zhao-Jun Song Bao-Rong Zhang Wen-Ying Long Guo-Hua Zhao 
the Research Foundation of Zhejiang Health,No.2020RC061。
BACKGROUND Type 1 sialidosis,also known as cherry-red spot-myoclonus syndrome,is a rare autosomal recessive lysosomal storage disorder presenting in the second decade of life.The most common symptoms are myoclonus,ata...
关键词:Sialidosis MYOCLONUS ATAXIA Neuraminidase 1 Case report Mucolipidoses 
Insights from investigating the interactions of natural product inhibitors with neuraminidase of the 2009 H1N1 influenza virus
《Journal of Chinese Pharmaceutical Sciences》2020年第6期390-397,共8页Yurui Jin Aixiu Li Jiaxiong Kang 
National Nature Science Foundation of China (Grant No. 81241114);Basic Research Project of Logistics University of PAP (Grant No. WHJ201401);Fund for Scientific Research and Innovation Team of Logistics University of PAP。
Neuraminidase(NA) plays a biologically vital role in the replication of influenza virus, and NA inhibitors(NAIs) are most widely used in the clinical anti-flu therapy. NA of 2009 H1 N1 influenza virus(09 N1) possesses...
关键词:2009 H1N1 influenza virus NEURAMINIDASE INHIBITOR Natural product Molecular docking 
Sheng Jiang San, traditional multi-herb formulation, exerts anti-influenza effects in vitro and in vivo via neuraminidaseinhibition and immune regulation
《中国药理学与毒理学杂志》2019年第9期738-739,共2页ZHANG Tian-bo XIAO Meng-jie Chun-Kwok WONG Ka-Pun CHRIS MOK ZHAO Xin TI Hui-hui Pang-Chui SHAW 
OBJECTIVE Sheng Jiang San(SJS),a multi-herb formulation,is used in treating high fever,thirsty and anxiety in ancient China and it is sometimes used to treat seasonal influenza in modern.However,there is no evidenceba...
关键词:Sheng Jiang San anti-influenza activity neuraminidase inhibition immuno-regulation 
Synthesis of Chaicone Derivatives Containing Furan or/and Pyran Ring as Neuraminidase Inhibitors被引量:1
《Chemical Research in Chinese Universities》2019年第3期395-402,共8页CHEN Aiyu LIANG Yongdong YE Jiao HU Aixi LIAN Wenwen LIU Ailin DU Guanhua 
the Hunan Provincial Natural Science Foundation,China(No.2019JJ40030);the National Natural Science Foundation of China(No.81673480).
Twenty-seven novel chaicone derivatives were designed and synthesized as neuraniinidase(NA) inhibitors. A concise suitable synthetic strategy was employed in the target compounds? synthesis with relatively high yields...
关键词:Chaicone DERIVATIVE NEURAMINIDASE INHIBITOR Molecular DOCKING 
Mutation-induced spatial differences in neuraminidase structure and sensitivity to neuraminidase inhibitors
《Chinese Physics B》2018年第1期145-153,共9页杨志伟 郝东晓 车一卓 杨嘉辉 张磊 张胜利 
Project supported by the National Natural Science Foundation of China(Grant Nos.11374237 and 11504287);Fundamental Research Funds for the Central Universities,China,China Postdoctoral Science Foundation(Grant No.2017M613147);Shaanxi Province Postdoctoral Science Foundation,China
Neuraminidase (NA), a major surface glycoprotein of influenza virus with well-defined active sites, is an ideal plat- form for the development of antiviral drugs. However, a growing number of NA mutations have drug ...
关键词:MUTATION active sites NEURAMINIDASE inhibitor sensitivity 
Multivalent neuraminidase hydrolysis resistant triazole-sialoside protein conjugates as influenza-adsorbents
《Chinese Chemical Letters》2018年第1期76-80,共5页Xin Meng Meibing Yang Yang Li Xiaobin Li Tianwei Jia Haojie He Qun Yu Na Guo Yun He Peng Yu Yang Yang 
financially supported by the National Natural Science Foundation of China(Nos.21402140,21502139);Shenzhen Peacock Plan(No. KQTD2016053114253158);Natural Science Foundation of Tianjin City(No. 16JCTPJC46000);Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education;Tianjin Key Lab of Industrial Microbiology(No. 2015IM107);Youth Innovation Research Foundation of Tianjin University of Science and Technology(No.2016LG08)
We report the synthesis of pseudo triazole-sialoside protein conjugates of various valency that are resistant to neuraminidase for the adsorption of influenza viruses. The glycotriazole monomer bearing an amine-functi...
关键词:Click chemistryMultivalent effectGlycoproteinDynamic light scatteringHemagglutinin/Neuraminidase inhibitor 
Screening and evaluation of commonly-used anti-influenza Chinese herbal medicines based on anti-neuraminidase activity被引量:6
《Chinese Journal of Natural Medicines》2016年第10期794-800,共7页HAN Xue ZHANG Ding-Kun GUO Yu-Ming FENG Wu-Wen DONG Qin ZHANG Cong-En ZHOU Yong-Feng LIU Yan WANG Jia-Bo ZHAO Yan-Ling XIAO Xiao-He YANG Ming 
supported by the National Natural Science Foundation of China(Nos.81274026,81403126,81330090,81573676)
Anti-influenza Chinese herbal medicines(anti-flu CHMs) have advantages in preventing and treating influenza virus infection. Despite various data on antiviral activities of some anti-flu CHMs have been reported, most ...
关键词:ANTI-INFLUENZA Chinese herbal medicines Viral neuraminidase BIOASSAY SCREENING Evaluation 
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