Ubiquitination in the regulation of autophagy  

作　　者：Xueyan Cen Ziling Li Xinpeng Chen 

机构地区：[1]Hubei Key laboratory of Edible Wild Plants Conservation&Utilization,Hubei Engineering Research Center of Special Wild Vegetables Breeding and Comprehensive Utilization Technology,School of Life Science,Hubei Normal University,Huangshi 435002,China [2]National Laboratory of Biomacromolecules,CAS Center for Excellence in Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Acta Biochimica et Biophysica Sinica》2023年第9期1348-1357,共10页生物化学与生物物理学报（英文版）

基　　金：supported by the grants from the National Natural Science Foundation of China(No.32100611);the Hubei Key Laboratory of Edible Wild Plants Conservation&Utilization(No.EWPL202004).

摘　　要：Autophagy,an efficient and effective approach to clear rapidly damaged organelles,macromolecules,and other harmful cellular components,enables the recycling of nutrient materials and supply of nutrients to maintain cellular homeostasis.Ubiquitination plays an important regulatory role in autophagy.This paper summarizes the most recent progress in ubiquitin modification in various stages of autophagy,including initiation,elongation,and termination.Moreover,this paper shows that ubiquitination is an important way through which selective autophagy achieves substrate specificity.Furthermore,we note the distinction between monoubiquitination and polyubiquitination in the regulation of autophagy.Compared with monoubiquitination,polyubiquitination is a more common strategy to regulate the activity of the autophagy molecular machinery.In addition,the role of ubiquitination in the closure and fusion of autophagosomes warrants further study.This article not only clarifies the regulatory mechanism of autophagy but also contributes to a deeper understanding of the importance of ubiquitination modification.

关 键 词：MONOUBIQUITINATION POLYUBIQUITINATION autophagy molecule machine selective autophagy 

分 类 号：R36[医药卫生—病理学]