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Sucrose induces flowering by degradation of the floral repressor Ghd7 via K48-linked polyubiquitination in rice: 《Journal of Integrative Plant Biology》2024年第12期2683-2700,共18页Lae-Hyeon Cho Jinmi Yoon Gibeom Baek Win Tun Hyeok Chan Kwon Dae-Woo Lee Seok-Hyun Choi Yang-Seok Lee Jong-Seong Jeon Gynheung An; supported in part by grants from the National Research Foundation of Korea (2020R1A2C2006826 to G.A.,2021R1C1C2007906 to J.Y.,2023R1A2C1003142 to J.-S.J.,and RS-2023-00208027 to L.-H.C.);the Rural Development Administration (RDA),Republic of Korea (RS-2022-RD010220); Sucrose functions as a signaling molecule in several metabolic pathways as well as in various developmental processes.However,the molecular mechanisms by which sucrose regulates these processes remain largely unknown....; 关键词：flowering time Ghd7 IPI1 K48-linked poly-ubiquitination RICE SUCROSE

Classical swine fever virus NS5A protein antagonizes innate immune response by inhibiting the NF-κB signaling被引量：1: 《Virologica Sinica》2023年第6期900-910,共11页Jinfu Sun Jiaying Li Liming Li Haixiao Yu Ping Ma Yingnan Wang Jinqi Zhu Zezhong Feng Changchun Tu; the National Nature Science Foundation of China(Grant No.31972677);the Construction Project of Liaoning Provincial Key Laboratory,China(2022JH13/10200026).; The NS5A non-structural protein of classical swine fever virus(CSFV)is a multifunctional protein involved in viral genomic replication,protein translation,assembly of infectious virus particles,and regulation of cellu...; 关键词：Classical swine fever virus(CSFV) NS5A NF-κB signaling NEMO POLYUBIQUITINATION Proteasomal degradation

Ubiquitination in the regulation of autophagy被引量：1: 《Acta Biochimica et Biophysica Sinica》2023年第9期1348-1357,共10页Xueyan Cen Ziling Li Xinpeng Chen; supported by the grants from the National Natural Science Foundation of China(No.32100611);the Hubei Key Laboratory of Edible Wild Plants Conservation&Utilization(No.EWPL202004).; Autophagy,an efficient and effective approach to clear rapidly damaged organelles,macromolecules,and other harmful cellular components,enables the recycling of nutrient materials and supply of nutrients to maintain ce...; 关键词：MONOUBIQUITINATION POLYUBIQUITINATION autophagy molecule machine selective autophagy

Ubiquitin-specific protease 24 promotes EV71 infection by restricting K63-linked polyubiquitination of TBK1被引量：5: 《Virologica Sinica》2023年第1期75-83,共9页Lichao Zang Jin Gu Xinyu Yang Yukang Yuan Hui Guo Wei Zhou Jinhong Ma Yan Chen Yumin Wu Hui Zheng Weifeng Shi; support was provided by the National Natural Science Foundation of China(81572052 and 82102473);Changzhou science and technology support plan(CE20225036,CJ20210141);Young Talent Development Plan of Changzhou Health Commission(2020-233).; TANK-binding kinase 1(TBK1)is an essential protein kinase for activation of interferon regulatory factor 3(IRF3)and induction of the type I interferons(IFN-I).Although the biochemical regulation of TBK1 activation has...; 关键词：Ubiquitin-specific protease 24(USP24) Enterovirus 71(EV71) TANK-binding kinase 1(TBK1) Type I interferons(IFN-I) Innate immunity

The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation被引量：1: 《Cellular & Molecular Immunology》2022年第10期1117-1129,共13页Lin-Wen Zeng Lu Feng Rui Liu Heng Lin Hong-Bing Shu Shu Li; This work was supported by grants from the National Natural Science Foundation of China(32188101,31830024 and 32070775);the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-071);the Fundamental Research Funds for the Central Universities.; Interleukin 5(IL-5)plays crucial roles in type 2-high asthma by mediating eosinophil maturation,activation,chemotaxis and survival.Inhibition of IL-5 signaling is considered a strategy for asthma treatment.Here,we ide...; 关键词：MARCH2/3 IL-5Rα POLYUBIQUITINATION EOSINOPHIL Airway inflammation

TRIM25 activates AKT/mTOR by inhibiting PTEN via K63-linked polyubiquitination in non-small cell lung cancer被引量：4: 《Acta Pharmacologica Sinica》2022年第3期681-691,共11页Yuan-ming He Xiu-min Zhou Shuo-yi Jiang Zu-bin Zhang Bi-yin Cao Jin-bao Liu Yuan-ying Zeng Jun Zhao Xin-liang Mao; This work was partly supported by the National Natural Science Foundation of China(#81672934 to JZ,#81770154 to XLM)by Suzhou Municipal Science and Technology Project for People’s Livelihood(#SYS201902 to YYZ).; The PTEN/AKT/mTOR signaling pathway is frequently dysregulated in non-small cell lung cancer(NSCLC),but the mechanisms are not well-understood.The present study found that the ubiquitin ligase TRIM25 is highly express...; 关键词：PTEN TRIM25 K63-linked polyubiquitination non-small cell lung cancer

MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα被引量：1: 《Signal Transduction and Targeted Therapy》2022年第2期519-530,共12页Lu Feng Chen Li Lin-Wen Zeng Deng Gao Yu-Hao Sun Li Zhong Heng Lin Hong-Bing Shu Shu Li; This work was supported by grants from the State Key R&D Program of China(2017YFA0505800);the National Natural Science Foundation of China(31830024 and 32070775);the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-071).; Interleukin-3(IL-3)is a hematopoietic growth factor and critical regulator of inflammatory response such as sepsis.IL-3 binds to IL-3 receptorα(IL-3Rα),which is then associated with IL-3Rβto initiate signaling.How ...; 关键词：INFLAMMATORY UBIQUITIN DAMAGE MARCH

The membrane-associated E3 ubiquitin ligase MARCH3 downregulates the IL-6 receptor and suppresses colitis-associated carcinogenesis被引量：3: 《Cellular & Molecular Immunology》2021年第12期2648-2659,共12页Heng Lin Lu Feng Kai-Sa Cui Lin-Wen Zeng Deng Gao Long-Xiang Zhang Wen-Hua Xu Yu-Hao Sun Hong-Bing Shu Shu Li; This work was supported by grants from the National Key R&D Program of China(2017YFA0505800);the National Natural Science Foundation of China(31630045,31830024,31900556,and 32070775);the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-071);the National Postdoctoral Program for Innovative Talents(BX20190255);the China Postdoctoral Science Foundation(2019M662706).; The IL-6-STAT3 axis is critically involved in inflammation-associated carcinogenesis(IAC).How this axis is regulated to modulate IAC remains unknown.Here,we show that the plasma membrane-associated E3 ubiquitin ligase...; 关键词：MARCH3 IL-6 IL-6Ra colitis-associated carcinogenesis POLYUBIQUITINATION

TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity被引量：1: 《Signal Transduction and Targeted Therapy》2021年第9期2794-2808,共15页Xueer Wang Honghai Zhang Zhugui Shao Wanxin Zhuang Chao Sui Feng Liu Xiaorong Chen Jinxiu Hou Lingli Kong Hansen Liu Yi Zheng Bingyu Liu Tian Chen Lei Zhang Xinming Jia Chengjiang Gao; This work was supported by grants from the National Natural Science Foundation of China(81930039,31730026,81525012);the Key Research and Development Projects of Shandong Province(2019GSF108133).; Spleen tyrosine kinase(SYK)is a non-receptor tyrosine kinase,which plays an essential role in both innate and adaptive immunity.However,the key molecular mechanisms that regulate SYK activity are poorly understood.Her...; 关键词：SYK IMMUNITY UBIQUITIN

Haploinsufficiency oftheTDP43 ubiquitin E3 ligase RNF220 leads to ALS-like motor neuron defects in the mouse: 《Journal of Molecular Cell Biology》2021年第5期374-382,共9页Pengcheng Ma Yuwei Li Huishan Wang Bingyu Mao; This work was supported by the National Natural Science Foundation of China(31671521 and 31871483 to B.M.);Yunnan Basic Research Program(202001AS070036 to B.M.).; TDP43 pathology is seen in a large majority of amyotrophic lateral sclerosis(ALS)cases,suggesting a central pathogenic role of this regulatory protein.Clarifying the molecular mechanism controlling TDP43 stability and...; 关键词：TDP43 RNF220 amyotrophic lateral sclerosis(ALS) POLYUBIQUITINATION

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