Retinoic acid signaling in fatty liver disease  

作　　者：Fathima N.Cassim Bawa Yanqiao Zhang 

机构地区：[1]Department of Integrative Medical Sciences,Northeast Ohio Medical University,Rootstown,OH,USA

出　　处：《Liver Research》2023年第3期189-195,共7页肝脏研究（英文）

基　　金：supported in part by the U.S.NIH grants DK102619 and DK118805 to Y.Z.Both figures were created with BioRender.com and are original.

摘　　要：Retinoic acid(RA)is a metabolite of vitamin A and is essential for development and growth as well as cellular metabolism.Through genomic and nongenomic actions,RA regulates a variety of physiological functions.Dysregulation of RA signaling is associated with many diseases.Targeting RA signaling has been proven valuable to human health.All-trans-RA(AtRA)and anthracycline-based chemotherapy are the standard treatment of acute promyelocytic leukemia(APL).Both human and animal studies have shown a significant relationship between RA signaling and the development and progression of nonalcoholic fatty liver disease(NAFLD).In this review article,we will first summarize vitamin A metabolism and then focus on the role of RA signaling in NAFLD.AtRA inhibits the development and progression of NAFLD by regulating lipid metabolism,inflammation,thermogenesis,etc.

关 键 词：Retinoic acid(RA) All-trans-RA(AtRA) Fatty liver disease Fatty acid oxidation LIPOGENESIS OBESITY 

分 类 号：R575.5[医药卫生—消化系统]