面向生物乙醇生产的酿酒酵母比较基因组序列分析研究进展  

Research Progress of Sequence Analysis of Comparative Genomes in Saccharomyces cerevisiae for Bioethanol Production

作　　者：许建韧 王岚[4] 马海军[1,2] XU Jian-ren;WANG Lan;MA Hai-jun(College of Bioscience and Engineering,North Minzu University,Yinchuan 750021,China;Ningxia Grape and Wine Technology Innovation Center,North Minzu University,Yinchuan 750021,China;Ningxia Key Laboratory for the Development and Application of Microbial Resources in Extreme Environments,North Minzu University,Yinchuan 750021,China;School of Food and Wine,Ningxia University,Yinchuan 750021,China)

机构地区：[1]北方民族大学生物科学与工程学院,银川750021 [2]北方民族大学宁夏葡萄与葡萄酒技术创新中心,银川750021 [3]北方民族大学宁夏特殊生境微生物资源开发与利用重点实验室,银川750021 [4]宁夏大学葡萄酒与园艺学院,银川750021

出　　处：《中国生物工程杂志》2023年第9期77-92,共16页China Biotechnology

基　　金：宁夏重点研发计划(2020BEB04013);宁夏自然科学基金(2021AAC03182)。

摘　　要：酿酒酵母是生物乙醇领域应用和研究的常用菌。综述了酿酒酵母基因组序列比较在提高基因功能注释准确性、发现不同菌株间分子结构变异、提供遗传育种潜在靶标基因等的相关研究,以及揭示酵母种间遗传进化关系,探究基因型与表型之间关联的研究进展。探讨了面向生物乙醇生产的酵母遗传育种,以满足工业生产需求。展望了随着测序菌株数量增多,酿酒酵母基因组的资源挖掘、重要价值和研究前景。Saccharomyces cerevisiae is a common strain used in the field of bioethanol production.This paper reviews recent progress of comparative studies on S.cerevisiae genomic sequences in improving the accuracy of gene functional annotation,discovering molecular variation among different strains,providing potential target genes for genetic breeding,as well as revealing interspecific genetic evolution of yeasts,and exploring the correlation between genotypes and phenotypes.Moreover,yeast genetic breeding for bioethanol production to meet the requirements of industrial production was further discussed,and some insightful views on the bioresource mining of the genome of Saccharomyces cerevisiae with the increasing number of genome-sequenced strains,its important value,and research prospects were also provided.

关 键 词：酿酒酵母 比较基因组 序列分析 遗传进化 生物乙醇 

分 类 号：Q815[生物学—生物工程]