Restoring expression of Stathmin-2:a novel strategy to treat TDP-43 proteinopathies  

作　　者：Sonja Menge Lorena Decker Axel Freischmidt 

机构地区：[1]Department of Neurology,Ulm University,89081 Ulm,Germany

出　　处：《Signal Transduction and Targeted Therapy》2023年第8期3553-3554,共2页信号转导与靶向治疗（英文）

基　　金：A.F.is supported by the Deutsche Forschungsgemeinschaft(DFG;grant#521487152).We apologize to all our colleagues whose work could not be cited here due to space limitations.

摘　　要：In a recent study published in Science,Baughn et al.revealed that TDP-43 acts as a steric block in STMN2 pre-mRNA processing preventing inclusion of a deleterious cryptic exon,and present strategies for substituting this function to compensate for the loss of nuclear TDP-43 in a variety of neurodegenerative diseases(NDs)including amyotrophic lateral sclerosis(ALS).1 Stathmin-2(STMN2)is a microtubule-associated protein speci-fically expressed in neurons and required for axon outgrowth and maintenance,as well as for axon regeneration after injury in vitro.

关 键 词：STATHMIN DISEASES 

分 类 号：R741[医药卫生—神经病学与精神病学]