KRAB-ZFPs and cancer stem cells  

作　　者：Anna Olechnowicz Urszula Oleksiewicz Marta Machnik 

机构地区：[1]Department of Cancer Immunology,Poznan University of Medical Sciences,Poznan 60-806,Poland [2]Department of Histology and Embryology,Poznan University of Medical Sciences,Poznan 60-781,Poland [3]Doctoral School,Poznan University of Medical Sciences,Poznan 60-812,Poland [4]Department of Cancer Diagnostics and Immunology,Greater Poland Cancer Centre,Poznan 61-866,Poland

出　　处：《Genes & Diseases》2023年第5期1820-1832,共13页基因与疾病（英文）

基　　金：supported by the National Science Centre,Poland:2015/17/B/NZ2/03689 to Urszula Oleksiewicz;2018/31/D/NZ3/03790 to Marta Machnik.

摘　　要：Studies on carcinogenesis continue to provide new information about different disease-related processes.Among others,much research has focused on the involvement of cancer stem cells(CSCs)in tumor initiation and progression.Studying the similarities and dif-ferences between CSCs and physiological stem cells(SCs)allows for a better understanding of cancer biology.Recently,it was shown that stem cell identity is partially governed by the Kruppel-associated box domain zinc finger proteins(KRAB-ZFPs),the biggest family of tran-scription regulators.Several KRAB-ZFP factors exert a known effect in tumor cells,acting as tumor suppressor genes(TSGs)or oncogenes,yet their role in CSCs is still poorly characterized.Here,we review recent studies regarding the influence of KRAB-ZFPs and their cofactor pro-tein TRIM28 on CSCs phenotype,stemness features,migration and invasion potential,metas-tasis,and expression of parental markers.

关 键 词：CANCER Cancer stem cell EPIGENETIC KRAB-ZFP Transcription factors 

分 类 号：R73[医药卫生—肿瘤]