Chemogenetic Therapeutics: A Powerful Tool to Control Cortical Seizures in Non-human Primates  

作　　者：Lin Yang Mengdi Zhang Yi Wang Zhong Chen 

机构地区：[1]Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province,School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China [2]Zhejiang Rehabilitation Medical Center Department,The Third Afliated Hospital,Zhejiang Chinese Medical University,Hangzhou 310013,China [3]Epilepsy Center,Second Afliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,China

出　　处：《Neuroscience Bulletin》2023年第10期1601-1604,共4页神经科学通报（英文版）

基　　金：This research highlight was supported by grants from the National Key R&D Program of China(2020YFA0803902);the National Natural Science Foundation of China(82022071);the Natural Science Foundation of Zhejiang Province(LD22H310003).

摘　　要：The Basis for Investigating the Role of DREADDs in Epilepsy in Non-human Primates Epilepsy is one of the common neurological disorders,characterized by spontaneous and recurrent seizures.Its etiology and pathophysiology are complicated,where the imbalance of excitatory glutamate and inhibitory GABAergic neurotransmission is well documented[1].Frontal lobe epilepsy(FLE)is the second most common focal epilepsy.

关 键 词：EPILEPSY THERAPEUTIC seizures 

分 类 号：R741[医药卫生—神经病学与精神病学]