The role of circadian clocks in cancer:Mechanisms and clinical implications  

作　　者：Huiwen Liu Ying Liu Rihan Hai Weihua Liao Xiangjian Luo 

机构地区：[1]Key Laboratory of Carcinogenesis and Invasion,Chinese Ministry of Education,Department of Radiology,Xiangya Hospital,Central South University,Changsha,Hunan 410078,China [2]Cancer Research Institute,School of Basic Medicine,Central South University,Changsha,Hunan 410078,China [3]Department of Medicine,Hunan Traditional Chinese Medical College,Zhuzhou,Hunan 412000,China [4]Molecular Imaging Research Center of Central South University,Changsha,Hunan 410078,China [5]Hunan Key Laboratory of Oncotarget Gene,Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha,Hunan 410078,China [6]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan 410078,China

出　　处：《Genes & Diseases》2023年第4期1279-1290,共12页基因与疾病（英文）

基　　金：supported by grants from the National Natural Science Foundation of China(No.81874195,82173144);the Natural Science Foundation of Hunan Province(No.2020JJ4769);the Fundamental Research Funds for the Central Universities of Central South University(No.2021zzts0925);the Open-End Fund for the Valuable and Precision Instruments of Central South University(No.CSUZC202237).

摘　　要：Circadian rhythm refers to the inherent 24-h cycle oscillation of biochemical,phys-iological and behavioral functions,which is almost universal in eukaryotes.At least 14 core clock genes have been reported to form multiple chain feedback loops that confer intrinsic circadian rhythmicity onto the molecular clock.Accumulating evidence has shown that the circadian gene dysfunction resulted from single nucleotide polymorphisms(SNPs),deletions,epigenetic modification,and deregulation is strongly associated with cancer risk.In the pre-sent review,we describe the composition of circadian rhythm system.We highlight the func-tion and mechanism of clock genes in cancer pathogenesis and progression.Moreover,their potential clinical implications as prognostic biomarkers and therapeutic targets have been ad-dressed.

关 键 词：CANCER Cancer metabolism Circadian clock Circadian rhythm CHRONOTHERAPY Tumor microenvironment 

分 类 号：R73[医药卫生—肿瘤]