Resting-state electroencephalography theta predicts neurofeedback treatment 4-month follow-up response in nicotine addiction  

作　　者：Qiujian Meng Ying Zhu Ye Yuan Li Yang Jiafang Liu Xiaochu Zhang Junjie Bu 

机构地区：[1]Department of Intelligent Medical Engineering,School of Biomedical Engineering,Anhui Medical University,Hefei,Anhui,China [2]Department of Psychology,School of Mental Health and Psychological Sciences,Anhui Medical University,Hefei,Anhui,China [3]Department of Psychology,School of Humanities&Social Science,University of Science&Technology of China,Hefei,Anhui,China [4]Department of Radiology,the First Affiliated Hospital of USTC,Hefei National Research Center for Physical Sciences at the Microscale and School of Life Science,Division of Life Science and Medicine,University of Science&Technology of China,Hefei,Anhui,China [5]Application Technology Center of Physical Therapy to Brain Disorders,Institute of Advanced Technology,University of Science&Technology of China,Hefei,Anhui,China [6]Institute of Health and Medicine,Hefei Comprehensive Science Center,Hefei,Anhui,China

出　　处：《General Psychiatry》2023年第4期303-311,共9页综合精神医学（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(32000750,32171080,71942003,and 32161143022);Grants for Scientific Research of BSKY(XJ201907)from Anhui Medical University;Scientific Research Improvement Project of Anhui Medical University(2021xkjT018);Research Fund of Anhui Institute of Translational Medicine(2022zhyx-C02);Basic and Clinical Collaborative Research Improvement Project of Anhui Medical University(2020xkjT020);The Chinese National Programs for Brain Science and Brain-like Intelligence Technology(2021ZD0202101);CAS-VPST Silk Road Science Fund 2021(GLHZ202128).The numerical calculations in this paper have been done on the Medical Big Data Supercomputing Center System of Anhui Medical University and Bioinformatics Center of the University of Science and Technology of China.

摘　　要：Background The high rate of long-term relapse is a major cause of smoking cessation failure.Recently,neurofeedback training has been widely used in the treatment of nicotine addiction;however,approximately 30%of subjects fail to benefit from this intervention.Our previous randomised clinical trial(RCT)examined cognition-guided neurofeedback and demonstrated a significant decrease in daily cigarette consumption at the 4-month follow-up.However,significant individual differences were observed in the 4-month follow-up effects of decreased cigarette consumption.Therefore,it is critical to identify who will benefit from pre-neurofeedback.Aims We examined whether the resting-state electroencephalography(EEG)characteristics from pre-neurofeedback predicted the 4-month follow-up effects and explored the possible mechanisms.Methods This was a double-blind RCT.A total of 60 participants with nicotine dependence were randomly assigned to either the real-feedback or yoked-feedback group.They underwent 6 min closed-eye resting EEG recordings both before and after two neurofeedback sessions.A follow-up assessment was conducted after 4 months.Results The frontal resting-state theta power spectral density(PSD)was significantly altered in the real-feedback group after two neurofeedback visits.Higher theta PSD in the real-feedback group before neurofeedback was the only predictor of decreased cigarette consumption at the 4-month follow-up.Further reliability analysis revealed a significant positive correlation between theta PSD pre-neurofeedback and post-neurofeedback.A leave-one-out cross-validated linear regression of the theta PSD pre-neurofeedback demonstrated a significant correlation between the predicted and observed reductions in cigarette consumption at the 4-month follow-up.Finally,source analysis revealed that the brain mechanisms of the theta PSD predictor were located in the orbital frontal cortex.Conclusions Our study demonstrated changes in the resting-state theta PSD following neurofeedback training.Moreover,the re

关 键 词：NICOTINE ADDICTION TREATMENT 

分 类 号：R74[医药卫生—神经病学与精神病学]