Physical exercise and synaptic protection in human and pre-clinical models of multiple sclerosis  

作　　者：Federica Azzolini Ettore Dolcetti Antonio Bruno Valentina Rovella Diego Centonze Fabio Buttari 

机构地区：[1]Unit of Neurology,IRCCS Neuromed,Pozzilli,Italy [2]Department of System Medicine,University of Tor Vergata,Rome,Italy [3]Synaptic Immunopathology Lab,Department of Systems Medicine,Tor Vergata University,Rome,Italy

出　　处：《Neural Regeneration Research》2024年第8期1768-1771,共4页中国神经再生研究（英文版）

摘　　要：In multiple sclerosis,only immunomodulato ry and immunosuppressive drugs are recognized as disease-modifying therapies.Howeve r,in recent years,several data from pre-clinical and clinical studies suggested a possible role of physical exe rcise as disease-modifying therapy in multiple sclerosis.Current evidence is sparse and often conflicting,and the mechanisms underlying the neuroprotective and antinflammatory role of exercise in multiple sclerosis have not been fully elucidated.Data,mainly derived from pre-clinical studies,suggest that exe rcise could enhance longterm potentiation and thus neuroplasticity,could reduce neuroinflammation and synaptopathy,and dampen astrogliosis and microgliosis.In humans,most trials focused on direct clinical and MRI outcomes,as investigating synaptic,neuroinflammato ry,and pathological changes is not straightfo rward compared to animal models.The present review analyzed current evidence and limitations in research concerning the potential disease-modifying therapy effects of exercise in multiple sclerosis in animal models and human studies.

关 键 词：disease-modifying behaviour endocannabinoid system long-term potentiation multiple sclerosis NEUROPLASTICITY NEUROPROTECTION physical exercise synaptopathy 

分 类 号：R744.51[医药卫生—神经病学与精神病学]