膳食类胡萝卜素和脂溶性维生素的肠道吸收机制研究进展:重点关注转运蛋白  

Research Progress in Intestinal Absorption Mechanism of Dietary Carotenoids and Fat-Soluble Vitamins:Focus on Transporters

作　　者：张育昆 陈祉晴 张俊林 周乐松 林燕平 曹庸[1] 刘晓娟[1] ZHANG Yukun;CHEN Zhiqing;ZHANG Junlin;ZHOU Lesong;LIN Yanping;CAO Yong;LIU Xiaojuan(Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods,College of Food Science,South China Agricultural University,Guangzhou 510642,China)

机构地区：[1]华南农业大学食品学院,广东省功能食品活性物重点实验室,广东广州510642

出　　处：《食品科学》2023年第21期282-292,共11页Food Science

基　　金：国家自然科学基金面上项目(32172195);广州市重点研发计划项目(SL2022B03J00806);广东省自然科学基金项目(2021A1515012158)。

摘　　要：类胡萝卜素和脂溶性维生素(carotenoids and fat-soluble vitamin,C&FSV)属于对机体健康有重要作用的高度亲脂性食品成分,主要通过外源性食物摄取。关于C&FSV的肠道吸收机制的认识已由最初的部分C&FSV通过简单扩散吸收发展到膳食C&FSV由特异转运蛋白介导吸收的新阶段。本文综述了C&FSV消化和吸收过程,重点关注转运蛋白介导下的肠细胞顶端转运、胞浆转运和细胞内代谢、肠细胞基底外侧膜分泌整个吸收过程的最新研究进展,同时对于C&FSV转运蛋白的调控进行了全面汇总,以期推动脂溶性活性物的肠道吸收机制研究进展,更好地发挥其健康效应。Carotenoids and fat-soluble vitamins(C&FSV)belong to the group of highly lipophilic food components that have important effects on the body’s health,which are ingested mainly through consumption of foods.The knowledge about the intestinal absorption mechanism of dietary C&FSV has been developed from partial C&FSV absorption through simple diffusion to specific transporter-mediated absorption of dietary C&FSV.This paper reviews the latest research progress in the process of digestion and absorption of C&FSV with special focus on,transporter-mediated apical transport,cytosolic transport and intracellular metabolism in enterocytes,and secretion from the basolateral membrane of enterocytes for the entire absorption process,and it provides a comprehensive summary of the regulation of C&FSV transporters.This review is expected to drive the understanding of the intestinal absorption mechanism of lipid-soluble bioactives so that they can better exert their beneficial health effects.

关 键 词：转运蛋白 类胡萝卜素 脂溶性维生素 肠道吸收 

分 类 号：TS201.4[轻工技术与工程—食品科学]