益生菌消化道耐受性的体外评价方法研究进展  

Research Progress on in Vitro Evaluation Method for The Digestive Tract Tolerance of Probiotics

作　　者：滕堃如 李斌 曹梦思 陈红贺 陈楠楠[1] 刘明[1] 郭新光[1] TENG Kunru;LI Bin;CAO Mengsi;CHEN Honghe;CHEN Nannan;LIU Ming;GUO Xinguang(China National Research Institute of Food and Fermentation Industries,Beijing 100015,China)

机构地区：[1]中国食品发酵工业研究院,北京100015

出　　处：《食品科技》2023年第11期41-49,共9页Food Science and Technology

基　　金：“十三五”国家重点研发计划重点专项(2019YFC1605203)。

摘　　要：一定数量的益生菌在机体肠道中可发挥有益的生理功效,但人体的消化道环境对微生物具有破坏甚至灭活作用,阻碍其益生特性的发挥,因此在益生菌的开发过程中需要采用体外模拟消化模型对其消化道耐受性进行评价。文章介绍了常用的体外模拟消化模型,重点对人体消化过程的生理参数以及现有体外消化模型的消化参数进行了综述,最后总结了体外模拟消化模型在益生菌研究中的具体应用,以期为益生菌消化道耐受性的标准化评价提供理论基础。An adequate number of probiotics can exert beneficial physiological effects in the host intestine.Still,the human digestive tract is destructive or even inactivating to microorganisms,so in vitro simulation digestion models need to be used to evaluate the digestive tract tolerance of probiotics.This summary first introduces the commonly used in vitro simulation digestion models,then focuses on the digestive parameters of the human digestive process and in vitro digestion models,and summarizes its specific application in probiotic research.This review intends to provide a theoretical basis for the standardized evaluation of the digestive tract tolerance of probiotics.

关 键 词：益生菌 消化道耐受性 体外模拟消化模型 人体消化过程 消化参数 

分 类 号：TS201.3[轻工技术与工程—食品科学]