Retrospective Study Efficacy of pantoprazole plus perforation repair for peptic ulcer and its effect on the stress response  

作　　者：Zi-Yan Leng Jia-Hao Wang Lei Gao Ke Shi Hai-Bing Hua 

机构地区：[1]The Second Hospital of Traditional Chinese Medicine of Jiangsu Province,Affiliated to Nanjing University of Chinese Medicine,Nanjing 210023,Jiangsu Province,China [2]Institute of Literature in Chinese Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,Jiangsu Province,China [3]School of Chinese Medicine&School of Integrated,Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,Jiangsu Province,China [4]Department of Spleen and Gastroenterology,Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine,Jiangyin 214400,Jiangsu Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2023年第12期2757-2764,共8页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND Peptic ulcer(PU)is an abnormal phenomenon in which there is rupture of the mucosa of the digestive tract,which not only affects patients'normal life but also causes an economic burden due to its high medical costs.AIM To investigate the efficacy of pantoprazole(PPZ)plus perforation repair in patients with PU and its effect on the stress response.METHODS The study subjects were 108 PU patients admitted between July 2018 and July 2022,including 58 patients receiving PPZ plus perforation repair[research group(RG)]and 50 patients given simple perforation repair[control group(CG)].The efficacy,somatostatin(SS)concentration,stress reaction[malondialdehyde(MDA),lipid peroxide(LPO)],inflammatory indices[tumor necrosis factor(TNF)-α,C-reactive protein(CRP),interleukin(IL)-1β],recurrence,and complications(perforation,hemorrhage,and pyloric obstruction)were compared.RESULTS The overall response rate was higher in the RG than in the CG.Patients in the RG and IL-1β were significantly reduced to lower levels than those in the CG.Lower recurrence and complication rates were identified in the RG group.CONCLUSION Therefore,PPZ plus perforation repair is conducive to enhancing treatment outcomes in PU patients,reducing oxidative stress injury and excessive inflammatory reactions,and contributing to low recurrence and complication rates.

关 键 词：PANTOPRAZOLE Perforation repair Peptic ulcer EFFICACY Etress response 

分 类 号：R57[医药卫生—消化系统]