人乳低聚糖与肠道菌群互作及其调节婴儿免疫功能的研究进展  

Research Progress on HMOs Interacting with Intestinal Flora to Regulate Infant Immune Function

作　　者：徐颢轩 刘婧雯 尚佳萃 孟祥晨[1] XU Haoxuan;LIU Jingwen;SHANG Jiacui;MENG Xiangchen(College of Food Science,Northeast Agricultural University,Key Laboratory of Dairy Science,Ministry of Education,Harbin 150030,China)

机构地区：[1]东北农业大学食品学院,乳品科学教育部重点实验室,黑龙江哈尔滨150030

出　　处：《食品工业科技》2024年第3期363-371,共9页Science and Technology of Food Industry

基　　金：国家自然科学基金项目(32272291)。

摘　　要：人乳低聚糖(human milk oligosaccharides,HMOs)是母乳中的一类重要组分,迄今为止已经确定了200多种结构不同的HMOs。HMOs能在肠道微生物的作用下产生短链脂肪酸,对婴儿健康产生有益影响,这是母乳与配方粉的主要区别之一。研究表明,不同种类的肠道微生物利用不同机制来识别和消化不同结构的HMOs,维持肠道菌群平衡。同时,HMOs还具有缓解过敏症状,预防坏死性小肠结肠炎等多种功能。本文对HMOs的结构、种类与含量、与婴儿肠道菌群的互作及其免疫调节功能进行了综述。HMOs可促进婴儿肠道菌群的定植与生长,并通过多种方式直接或间接调节婴儿免疫功能。本文为HMOs在婴幼儿食品中的应用提供理论支持,对其未来研发方向提供新思路。Human milk oligosaccharides(HMOs)are very important components in human milk,and more than 200 different HMOs have been identified so far.HMOs act as prebiotics by the metabolism of gut microbiota to produce short-chain fatty acids,which have a beneficial effect on infant health.This is one of the main differences between breast milk and formula milk powder.Studies have shown that different species of gut microbiota use different mechanisms to recognize and digest HMOs with different structures,maintaining the balance of the gut microbiota.HMOs also have a variety of functions such as relieving allergic symptoms and preventing necrotizing enterocolitis.In this paper,the type,structure and content of HMOs,interaction between HMOs and infant gut microbiota,and their immune regulatory functions are reviewed.HMOs can promote colonization and growth of gut microbiota in infants,and directly or indirectly regulate the infant immune function.This paper provides theoretical support for the application of HMOs in infant foods,and contributes new ideas to the future research and development direction.

关 键 词：母乳低聚糖 岩藻糖基化 肠道菌群 免疫 抵抗病原体粘附 

分 类 号：TS201.2[轻工技术与工程—食品科学]