Resveratrol as an epigenetic therapy for flavivirus infection:A narrative review  

作　　者：Kim-Ling Chin Kim-Kee Tan Sazaly Abu Bakar Nurhafiza Zainal 

机构地区：[1]Department of Medical Microbiology,Faculty of Medicine,Universiti Malaya,Kuala Lumpur,Malaysia [2]Institute for Advanced Studies,Universiti Malaya,Kuala Lumpur,Malaysia [3]Tropical Infectious Diseases Research and Education Centre(TIDREC),Universiti Malaya,Kuala Lumpur,Malaysia

出　　处：《Asian Pacific Journal of Tropical Medicine》2023年第12期546-557,I0001-I0013,共25页亚太热带医药杂志（英文版）

基　　金：funding from the Ministry of Higher Education,Malaysia for niche area research under the Higher Institution Centre of Excellence(HICoE)program(MO002-2019&TIDREC-2023).

摘　　要：Flaviviruses are a group of positive-stranded RNA viruses that cause a broad spectrum of severe illnesses in humans worldwide.Clinical manifestations of flavivirus infections range from mild febrile illness to hemorrhage,shock,and neurological manifestations.Flavivirus infections cause a substantial global health impact,with an estimated more than 400 million cases of infections annually.Hence,an understanding of flavivirus-host interaction is urgently needed for new antiviral therapeutic strategies.In recent years,many aspects concerning epigenetic therapy for viral infections have been addressed,including methylation of the genome,acetylation/deacetylation of histone complex and microRNA regulation.In this context,we surveyed and reviewed the literature and summarized the epigenetic effects of resveratrol,a natural polyphenol with potential anti-viral properties,on flavivirus infections.

关 键 词：Infectious diseases Epigenetic RESVERATROL FLAVIVIRUS DNA methylation HISTONE Non-histone proteins MICRO-RNA 

分 类 号：R373[医药卫生—病原生物学]