The Vγ4/butyrophilin conspiracy: novel role of intraepithelial γδ T cells in chronic inflammatory bowel disease  

作　　者：Dieter Kabelitz 

机构地区：[1]Institute of Immunology,Christian-Albrechts University Kiel and University Hospital Schleswig-Holstein Campus Kiel,Kiel,Germany

出　　处：《Signal Transduction and Targeted Therapy》2023年第12期5575-5577,共3页信号转导与靶向治疗（英文）

基　　金：Open Access funding enabled and organized by Projekt DEAL.

摘　　要：In a recent article published in Science,Dart and colleagues reported that colonic T cells expressing the Vγ4 T-cell receptor(TCR)interact with epithelial butyrophilin-like(BTNL)proteins BTNL3 and BTNL8 in healthy individuals,and they observed a depletion of Vγ4 T cells in inflammatory bowel diseases with renormalization associated with disease remission.1 This paper identifies the BTNL/Vγ4 axis as a new disease modifier in IBD.

关 键 词：BOWEL INFLAMMATORY DISEASES 

分 类 号：R574[医药卫生—消化系统]