黄曲霉毒素B1诱导大鼠肝细胞凋亡率剂量效应模型的构建  

Dose-Response Modeling of Aflatoxin B1-Induced Apoptosis Rate in Rat Hepatocytes

作　　者：黄奥迪 严佳惠 张昭寰 刘海泉[1,2,3] 赵勇 欧杰[1,2,3] HUANG Aodi;YAN Jiahui;ZHANG Zhaohuan;LIU Haiquan;ZHAO Yong;OU Jie(College of Food Science&Technology,Shanghai Ocean University,Shanghai 201306,China;Shanghai Engineering Research Center of Aquatic Product Processing&Preservation,Shanghai 201306,China;Laboratory of Quality&Safety Risk Assessment for Aquatic Products on Storage and Preservation(Shanghai),Ministry of Agriculture and Rural Affairs,Shanghai 201306,China)

机构地区：[1]上海海洋大学食品学院,上海201306 [2]上海水产品加工及贮藏工程技术研究中心,上海201306 [3]农业农村部水产品贮藏保鲜质量安全风险评估实验室(上海),上海201306

出　　处：《食品科学》2024年第3期61-67,共7页Food Science

基　　金：“十三五”国家重点研发计划重点专项(2018YFC1602205)。

摘　　要：通过黄曲霉毒素B1(aflatoxin B1,AFB1)诱导大鼠肝细胞凋亡的定量数据,从而构建AFB1诱导大鼠肝细胞凋亡率的剂量效应模型。通过拟合模型获取决定系数和进一步的数学检验表明,Gamma模型(R2=0.996 4,赤池信息量准则=37.40,贝叶斯信息准则=17.19)优于其他模型。建议选用Gamma模型作为大鼠急性暴露于AFB1后肝细胞凋亡率的最优剂量效应模型,用于AFB1风险评估框架中的危害特征描述。This study aimed to construct a dose-response model of aflatoxin B1(AFB1)-induced apoptosis rate in rat hepatocytes by using quantitative data.The coefficients of determination(R2)and further mathematical tests showed that the 2 Gamma model(R=0.9964,Akaike information criterion=37.40,and Bayesian information criterion=17.19)was superior to other models.Hence,the Gamma model was recommended as the optimal dose-response model for apoptosis rate in rat hepatocytes after acute exposure to AFB1 for hazard characterization in the framework of AFB1 risk assessment.

关 键 词：黄曲霉毒素B1 肝细胞凋亡 风险评估 剂量效应模型 

分 类 号：TS201.6[轻工技术与工程—食品科学]