Apoer2/Lrp8:the undercover cop of synaptic homeostasis  

作　　者：Gordon C.Werthmann Joachim Herz 

机构地区：[1]Department of Molecular Genetics and Center for Translational Neurodegeneration Research,University of Texas Southwestern Medical Center at Dallas,Dallas,TX,USA [2]Department of Neuroscience [3]Department of Neurology [4]University of Texas Southwestern Medical Center at Dallas,Dallas,TX,USA

出　　处：《Neural Regeneration Research》2024年第12期2563-2564,共2页中国神经再生研究（英文版）

基　　金：supported by NIH grants NS093382,NS108115,AG053391,HL063762 (to JH);supported by Blue Field Project to Cure FTD,BrightFocus Foundation (A20135245 and A2016396S)。

摘　　要：Apolipoprotein E receptor 2(ApoER2)is a receptor for the protein ApoE,the most common genetic risk factor for late-onset Alzheimer's disease(AD).It is also a key modulator of syna ptic homeostasis,in part through its effect on the expression of neuronal genes including those implicated in AD and other neuropsychiatric disorders.In this perspective,we highlight several genes affected by ApoER2 and its alternatively spliced forms and how aberrant expression can be rescued by the reintroduction of the ApoER2 intracellular domain in the mouse hippocampus.

关 键 词：HOMEOSTASIS APOE ALZHEIMER 

分 类 号：R749.16[医药卫生—神经病学与精神病学]