The role of inflammasomes in human diseases and their potential as therapeutic targets  

作　　者：Jing Yao Keenan Sterling Zhe Wang Yun Zhang Weihong Song 

机构地区：[1]The National Clinical Research Center for Geriatric Disease,Xuanwu Hospital,Capital Medical University,Beijing 100053,China [2]Townsend Family Laboratories,Department of Psychiatry,Brain Research Center,The University of British Columbia,2255 Wesbrook Mall,Vancouver,BC V6T 1Z3,Canada [3]Key Laboratory of Neurodegenerative Diseases,Ministry of Education,Beijing,P.R.China [4]Zhejiang Clinical Research Center for Mental Disorders,Key Laboratory of Alzheimer’s Disease of Zhejiang Province,School of Mental Health and The Affiliated Kangning Hospital,Institute of Aging,Wenzhou Medical University,Wenzhou,Zhejiang 325000,China [5]Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou,Zhejiang 325000,China

出　　处：《Signal Transduction and Targeted Therapy》2024年第2期479-508,共30页信号转导与靶向治疗（英文）

基　　金：supported by the Key Laboratory of Alzheimer’s Disease of Zhejiang Province(ZJAD-2021004);the National Natural Science Foundation of China(82201576);Beijing Hospitals Authority Youth Programme(QML20210804);Beijing Medical Research 2021-8(YZ);the National Natural Science Foundation of China(82150710557,82230043 and 82293642)to WS.

摘　　要：Inflammasomes are large protein complexes that play a major role in sensing inflammatory signals and triggering the innate immune response.Each inflammasome complex has three major components:an upstream sensor molecule that is connected to a downstream effector protein such as caspase-1 through the adapter protein ASC.Inflammasome formation typically occurs in response to infectious agents or cellular damage.The active inflammasome then triggers caspase-1 activation,followed by the secretion of pro-inflammatory cytokines and pyroptotic cell death.Aberrant inflammasome activation and activity contribute to the development of diabetes,cancer,and several cardiovascular and neurodegenerative disorders.As a result,recent research has increasingly focused on investigating the mechanisms that regulate inflammasome assembly and activation,as well as the potential of targeting inflammasomes to treat various diseases.Multiple clinical trials are currently underway to evaluate the therapeutic potential of several distinct inflammasome-targeting therapies.Therefore,understanding how different inflammasomes contribute to disease pathology may have significant implications for developing novel therapeutic strategies.In this article,we provide a summary of the biological and pathological roles of inflammasomes in health and disease.We also highlight key evidence that suggests targeting inflammasomes could be a novel strategy for developing new disease-modifying therapies that may be effective in several conditions.

关 键 词：inflam THERAPEUTIC POTENTIAL 

分 类 号：R741[医药卫生—神经病学与精神病学]