ALKBH5 gene polymorphisms and risk of neuroblastoma in Chinese children from Jiangsu Province  

作　　者：Qian Guan Xinxin Zhang Jiabin Liu Chunlei Zhou Jinhong Zhu Haiyan Wu Zhenjian Zhuo Jing He 

机构地区：[1]Department of Pediatric Surgery,Guangzhou Institute of Pediatrics,Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease,Guangdong Provincial Clinical Research Center for Child Health,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou,Guangdong,China [2]Department of Pathology,Children's Hospital of Nanjing Medical University,Nanjing,Jiangsu,China [3]Department of Clinical Laboratory,Biobank,Harbin Medical University Cancer Hospital,Harbin,Heilongjiang,China [4]Laboratory Animal Center,School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School,Shenzhen,Guangdong,China

出　　处：《Cancer Innovation》2024年第2期72-79,共8页肿瘤创新（英文）

基　　金：Science,Technology and Innovation Commission of Shenzhen,Grant/Award Number:JCYJ20220531093213030;Postdoctoral Science Foundation of Jiangsu Province,Grant/Award Number:2021K524C;Postdoctoral Science Foundation of China,Grant/Award Number:2021M691649;National Natural Science Foundation of China,Grant/Award Numbers:82002636,82173593;Guangzhou Science and Technology Project,Grant/Award Numbers:202102020421,202201020622。

摘　　要：Background:Neuroblastoma is one of the most common extracranial malignant solid tumors in children.AlkB homolog 5(ALKBH5)is an RNA N6-methyladenosine(m6A)demethylase that plays a critical role in tumorigenesis and development.We assessed the association between single nucleotide polymorphisms(SNPs)in ALKBH5 and the risk of neuroblastoma in a case-control study including 402 patients and 473 non-cancer controls.Methods:Genotyping was determined by the TaqMan method.The association between ALKBH5 polymorphisms(rs1378602 and rs8400)and the risk of neuroblastoma was evaluated using the odds ratio(OR)and 95%confidence interval(CI).Results:We found no strong association of ALKBH5 rs1378602 and rs8400 with neuroblastoma risk.Further stratification analysis by age,sex,primary site,and clinical stage showed that the rs1378602 AG/AA genotype was associated with a lower risk of neuroblastoma in males(adjusted OR=0.58,95%CI=0.35–0.97,p=0.036)and children with retroperitoneal neuroblastoma(adjusted OR=0.58,95%CI=0.34–0.98,p=0.040).Conclusions:ALKBH5 SNPs do not seem to be associated with neuroblastoma risk.More studies are required to confirm this negative result and reveal the relationship between gene polymorphisms of the m6A modifier ALKBH5 and neuroblastoma.

关 键 词：ALKBH5 NEUROBLASTOMA POLYMORPHISM SUSCEPTIBILITY 

分 类 号：R739.4[医药卫生—肿瘤]