Cisplatin-appended BODIPY for near infraredⅡfluorescent and photoacoustic imaging-guided synergistic phototherapy and chemotherapy of cancer  

作　　者：Xuejian Xing E Pang Shaojing Zhao Tangna Pan Qiuxia Tan Benhua Wang Xiangzhi Song Minhuan Lan 

机构地区：[1]Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety,College of Chemistry and Chemical Engineering,Central South University,Changsha 410083,China

出　　处：《Chinese Chemical Letters》2024年第3期352-357,共6页中国化学快报（英文版）

基　　金：supported by National Natural Science Foundation of China(No.62175262);the Science and Technology Innovation Program of Hunan Province(No.2022RC1201);the Fundamental Research Funds for the Central Universities of Central South University(No.2019zzts849)。

摘　　要：Combining phototherapy and chemotherapy has been considered a promising modality for cancer therapy due to their synergistic effect.Herein,we developed three D-π-A-structured boron dipyrromethenes(BODIPYs)(named as B-B,B-C,and B-C-Pt).Due to their enlargedπ-conjugated structure and high intramolecular charge transfer effect,the synthesized BODIPYs had photothermal conversion capability,and their absorption and fluorescence spectra were red-shifted.The cisplatin-appended BODIPY(B-C-Pt)exhibited good singlet oxygen(^1O_(2))generation ability and near infrared(NIR)absorption and fluorescence(λ_(Abs)=748 nm,λ_(Em)=947 nm).After being encapsulated by distearoyl phosphoethanolamine polyethyleneglycol 2000(DSPE-PEG-2000),which could inhibit the H-aggregation of B-C-Pt,the absorption and fluorescence of the obtained B-C-Pt nanoparticles(NPs)were red-shifted to 762 and 985 nm,respectively.The^1O_(2)quantum yield and photothermal conversion efficiency of the B-C-Pt NPs were 4.0%and 40.6%,respectively.Moreover,B-C-Pt NPs had chemotherapeutic efficacy due to the presence of cisplatin.In vitro and in vivo studies further demonstrated that B-C-Pt NPs had synergistic therapeutic efficacy.Together,B-C-Pt NPs could be employed in NIRⅡfluorescent and photoacoustic imaging-guided synergistic phototherapy and chemotherapy for cancer treatment.

关 键 词：PHOTOTHERAPY CHEMOTHERAPY CISPLATIN BODIPY NIRⅡfluorescent imaging 

分 类 号：R730.5[医药卫生—肿瘤] O657.3[医药卫生—临床医学]