Chemotherapy induces breast cancer stem cell enrichment through repression of glutathione S-transferase Mu  

作　　者：Jing He Yiran Yu Yilin He Jie He Guangyu Ji Haiquan Lu 

机构地区：[1]The Second Hospital and Advanced Medical Research Institute,Cheeloo College of Medicine,Shandong University,Jinan,Shandong 250012,China [2]Department of Nursing,The First Affiliated Hospital of Shandong First Medical University,Jinan,Shandong 250014,China [3]School of Medicine,Xinjiang Medical University,Urumqi,Xinjiang 830054,China [4]School of Medicine,Binzhou Medical University,Yantai,Shandong 264003,China [5]Oncology Department,Jinan Zhangqiu District People's Hospital,Jinan,Shandong 250200,China [6]Key Laboratory for Experimental Teratology of the Ministry of Education,Cheeloo College of Medicine,Shandong University,Jinan,Shandong 250012,China [7]Center for Reproductive Medicine,Shandong University,Jinan,Shandong 250012,China

出　　处：《Genes & Diseases》2024年第2期528-531,共4页基因与疾病（英文）

基　　金：supported by the Natural Science Foundation of Shandong Province,China(No.ZR2021YQ50,Excellent Young Scholars Program)

摘　　要：Triple-negative breast cancer(TNBC)has aggressive characteristics as exemplified by the high risk of recurrence,metastasis,and patient mortality.1 Cytotoxic chemotherapy may reduce tumor burden initially,but leave behind chemo-resistant breast cancer stem cells(BCSCs)that lead to tumor recurrence and metastasis.2 Chemotherapy induces BCsC enrichment through the activation of glutathione biosynthesis pathways,which increases intracellular glutathione levels and specifies the BCSC phenotype through complicated downstream signaling pathways.3 Glutathione S-transferases(GSTs),a superfamily(which contains seven cytosolic classes:Alpha,Kappa,Mu,Omega,Pi,Theta,and Zeta,and one microsomal class MGSTs)of phase Il enzymes that catalyze the conjugation of glutathione with electrophilic compounds,play a critical role in detoxification and chemotherapy resistance of cancer cells.However,the role of GSTs in the regulation of BCSCs is largely elusive.

关 键 词：CHEMOTHERAPY BREAST METASTASIS 

分 类 号：R735.7[医药卫生—肿瘤]